Identification and Structural Characterization of I84C and I84A Mutations That Are Associated with High-Level Resistance to Human Immunodeficiency Virus Protease Inhibitors and Impair Viral Replication

• Published in: Antimicrobial Agents and Chemotherapy Vol. 51; no. 2; pp. 732 - 735
• Main Authors: HONGMEI MO, PARKIN, Neil, STEWART, Kent D, LIANGJUN LU, DEKHTYAR, Tatyana, KEMPF, Dale J, MOLLA, Akhteruzzaman
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.2007
• Subjects: Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Atazanavir Sulfate; Biological and medical sciences; Drug Resistance, Viral; Drug Resistance, Viral - genetics; Genes, gag; HIV Infections; HIV Infections - drug therapy; HIV Infections - genetics; HIV Infections - virology; HIV Protease Inhibitors; HIV Protease Inhibitors - pharmacology; HIV-1; HIV-1 - drug effects; HIV-1 - genetics; Human immunodeficiency virus; Humans; Indinavir - pharmacology; Medical sciences; Mutation; Nelfinavir - pharmacology; Oligopeptides - pharmacology; Pharmacology. Drug treatments; Pyridines - pharmacology; Ritonavir - pharmacology; Saquinavir - pharmacology; Virus Replication - genetics; Retroviridae; Identification; Lentivirus; Infection; Virus; Resistance; Viral disease; Antiviral; Genetics; Replication; Mutation; Human immunodeficiency virus; Protease inhibitor

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