Identification and Structural Characterization of I84C and I84A Mutations That Are Associated with High-Level Resistance to Human Immunodeficiency Virus Protease Inhibitors and Impair Viral Replication

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Published inAntimicrobial Agents and Chemotherapy Vol. 51; no. 2; pp. 732 - 735
Main Authors HONGMEI MO, PARKIN, Neil, STEWART, Kent D, LIANGJUN LU, DEKHTYAR, Tatyana, KEMPF, Dale J, MOLLA, Akhteruzzaman
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.02.2007
Subjects
Anti-HIV Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Atazanavir Sulfate
Biological and medical sciences
Drug Resistance, Viral
Drug Resistance, Viral - genetics
Genes, gag
HIV Infections
HIV Infections - drug therapy
HIV Infections - genetics
HIV Infections - virology
HIV Protease Inhibitors
HIV Protease Inhibitors - pharmacology
HIV-1
HIV-1 - drug effects
HIV-1 - genetics
Human immunodeficiency virus
Humans
Indinavir - pharmacology
Medical sciences
Mutation
Nelfinavir - pharmacology
Oligopeptides - pharmacology
Pharmacology. Drug treatments
Pyridines - pharmacology
Ritonavir - pharmacology
Saquinavir - pharmacology
Virus Replication - genetics
Retroviridae
Identification
Lentivirus
Infection
Virus
Resistance
Viral disease
Antiviral
Genetics
Replication
Mutation
Human immunodeficiency virus
Protease inhibitor
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Department R4CQ, Building AP52N, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL 60064-6217. Phone: (847) 938-1094. Fax: (847) 938-2756. E-mail: Akhter.m.molla@abbott.com.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00690-06