Selective Effect of 2′,6′-Dihydroxy-4′-Methoxychalcone Isolated from Piper aduncum on Leishmania amazonensis

• Published in: Antimicrobial Agents and Chemotherapy Vol. 43; no. 5; pp. 1234 - 1241
• Main Authors: TORRES-SANTOS, E. C, LIMA MOREIRA, D, KAPLAN, M. A. C, MEIRELLES, M. N, ROSSI-BERGMANN, B
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.05.1999
• Subjects: Animals; Anti-Infective Agents; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Antiparasitic Agents - pharmacology; Antiparasitic Agents - therapeutic use; Biological and medical sciences; Cells, Cultured; Chalcone; Chalcone - analogs & derivatives; Chalcone - pharmacology; Chalcone - therapeutic use; Chalcones; Leishmania; Leishmania - drug effects; Leishmania amazonensis; Leishmaniasis, Cutaneous; Leishmaniasis, Cutaneous - drug therapy; Macrophages - drug effects; Macrophages - parasitology; Macrophages - ultrastructure; Mechanisms of Action: Physiological Effects; Medical sciences; Mice; Mice, Inbred BALB C; Microscopy, Electron; Pharmacology. Drug treatments; Piper aduncum; Plant Extracts; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plants - metabolism; Kinetoplastida; Protozoa; Toxicity; Inflorescence; Rodentia; Piperaceae; In vitro; Vertebrata; Mammalia; Mouse; Dicotyledones; Animal; Nitric oxide; Leishmania; Angiospermae; Parasiticid; Plant origin; Spermatophyta; Mechanism of action; Piper; Amastigote; Macrophage

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