Dopaminergic Abnormalities in Select Thalamic Nuclei in Schizophrenia: Involvement of the Intracellular Signal Integrating Proteins Calcyon and Spinophilin

• Published in: The American journal of psychiatry Vol. 162; no. 10; pp. 1859 - 1871
• Main Authors: Clinton, Sarah M., Ibrahim, Hisham M., Frey, Kirk A., Davis, Kenneth L., Haroutunian, Vahram, Meador-Woodruff, James H.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.10.2005; American Psychiatric Association
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Autoradiography; Biological and medical sciences; Clinical trials; Dopamine - metabolism; Dopamine - physiology; Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism; Female; Humans; Male; Medical sciences; Membrane Proteins - metabolism; Membrane Proteins - physiology; Microfilament Proteins - metabolism; Microfilament Proteins - physiology; Middle Aged; Nerve Tissue Proteins - metabolism; Nerve Tissue Proteins - physiology; Neurology; Neurotransmitters; Proteins; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychotropic drugs; Receptors, Dopamine - metabolism; Receptors, Dopamine - physiology; RNA, Messenger - metabolism; Schizophrenia; Schizophrenia - metabolism; Schizophrenia - physiopathology; Synaptic Transmission - physiology; Thalamic Nuclei - metabolism; Thalamic Nuclei - physiopathology; Tissue Distribution; Vesicular Monoamine Transport Proteins - metabolism; Psychosis; Human; Dopaminergic transmission; Dopamine; Central nervous system; Neurotransmitter; Schizophrenia; Thalamus; Catecholamine; Neurotransmission; Encephalon

OBJECTIVE: While both thalamic abnormalities and dopaminergic dysregulation have been separately implicated in the pathophysiology of schizophrenia, little is known about the possible dysfunction of molecules associated with dopaminergic neurotransmission in the thalamus in this illness. In this stu...