Viral Vectors for Gene Therapy: Translational and Clinical Outlook

• Published in: Annual review of biomedical engineering Vol. 17; p. 63
• Main Authors: Kotterman, Melissa A, Chalberg, Thomas W, Schaffer, David V
• Format: Journal Article
• Language: English
• Published: United States 07.12.2015
• Subjects: Clinical Trials as Topic; Dependovirus - genetics; Genetic Engineering; Genetic Therapy - methods; Genetic Vectors; Humans; Immunologic Deficiency Syndromes - therapy; Lentivirus - genetics; Retroviridae - genetics; Translational Medical Research; genotoxicity; retrovirus; adeno-associated virus; vector engineering; adenovirus; lentivirus

In a range of human trials, viral vectors have emerged as safe and effective delivery vehicles for clinical gene therapy, particularly for monogenic recessive disorders, but there has also been early work on some idiopathic diseases. These successes have been enabled by research and development effo...