Mass Spectrometry-Imaging Analysis of Active Ingredients in the Leaves of Taxus cuspidata
Background: Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the leaves of T. cuspidata. However, the precise spatial distribution of active ingredients in the leaves of T. cuspidata...
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| Published in | ACS omega Vol. 9; no. 16; pp. 18634 - 18642 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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American Chemical Society
23.04.2024
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| Abstract | Background: Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the leaves of T. cuspidata. However, the precise spatial distribution of active ingredients in the leaves of T. cuspidata is largely unknown. Results: in the present study, timsTOF flex MALDI-2 analysis was used to uncover the accumulation pattern of active ingredients in T. cuspidata leaves. In total, 3084 ion features were obtained, of which 944 were annotated according to the mass spectrometry database. The principal component analysis separated all of the detected metabolites into four typical leaf tissues: mesophyll cells, upper epidermis, lower epidermis, and vascular bundle cells. Imaging analysis identified several leaf tissues that specifically accumulated active ingredients, providing theoretical support for studying the regulation mechanism of compound biosynthesis. Furthermore, the relative accumulation levels of each identified compound were analyzed. Two flavonoid compounds, ligustroflavone and Morin, were identified with high content through quantitative analysis of the ion intensity. Conclusions: our data provides fundamental information for the protective utilization of T. cuspidata. |
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| AbstractList | Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the leaves of T. cuspidata. However, the precise spatial distribution of active ingredients in the leaves of T. cuspidata is largely unknown.BACKGROUNDTaxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the leaves of T. cuspidata. However, the precise spatial distribution of active ingredients in the leaves of T. cuspidata is largely unknown.in the present study, timsTOF flex MALDI-2 analysis was used to uncover the accumulation pattern of active ingredients in T. cuspidata leaves. In total, 3084 ion features were obtained, of which 944 were annotated according to the mass spectrometry database. The principal component analysis separated all of the detected metabolites into four typical leaf tissues: mesophyll cells, upper epidermis, lower epidermis, and vascular bundle cells. Imaging analysis identified several leaf tissues that specifically accumulated active ingredients, providing theoretical support for studying the regulation mechanism of compound biosynthesis. Furthermore, the relative accumulation levels of each identified compound were analyzed. Two flavonoid compounds, ligustroflavone and Morin, were identified with high content through quantitative analysis of the ion intensity.RESULTSin the present study, timsTOF flex MALDI-2 analysis was used to uncover the accumulation pattern of active ingredients in T. cuspidata leaves. In total, 3084 ion features were obtained, of which 944 were annotated according to the mass spectrometry database. The principal component analysis separated all of the detected metabolites into four typical leaf tissues: mesophyll cells, upper epidermis, lower epidermis, and vascular bundle cells. Imaging analysis identified several leaf tissues that specifically accumulated active ingredients, providing theoretical support for studying the regulation mechanism of compound biosynthesis. Furthermore, the relative accumulation levels of each identified compound were analyzed. Two flavonoid compounds, ligustroflavone and Morin, were identified with high content through quantitative analysis of the ion intensity.our data provides fundamental information for the protective utilization of T. cuspidata.CONCLUSIONSour data provides fundamental information for the protective utilization of T. cuspidata. is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the leaves of . However, the precise spatial distribution of active ingredients in the leaves of is largely unknown. in the present study, timsTOF flex MALDI-2 analysis was used to uncover the accumulation pattern of active ingredients in leaves. In total, 3084 ion features were obtained, of which 944 were annotated according to the mass spectrometry database. The principal component analysis separated all of the detected metabolites into four typical leaf tissues: mesophyll cells, upper epidermis, lower epidermis, and vascular bundle cells. Imaging analysis identified several leaf tissues that specifically accumulated active ingredients, providing theoretical support for studying the regulation mechanism of compound biosynthesis. Furthermore, the relative accumulation levels of each identified compound were analyzed. Two flavonoid compounds, ligustroflavone and Morin, were identified with high content through quantitative analysis of the ion intensity. our data provides fundamental information for the protective utilization of . Background: Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the leaves of T. cuspidata. However, the precise spatial distribution of active ingredients in the leaves of T. cuspidata is largely unknown. Results: in the present study, timsTOF flex MALDI-2 analysis was used to uncover the accumulation pattern of active ingredients in T. cuspidata leaves. In total, 3084 ion features were obtained, of which 944 were annotated according to the mass spectrometry database. The principal component analysis separated all of the detected metabolites into four typical leaf tissues: mesophyll cells, upper epidermis, lower epidermis, and vascular bundle cells. Imaging analysis identified several leaf tissues that specifically accumulated active ingredients, providing theoretical support for studying the regulation mechanism of compound biosynthesis. Furthermore, the relative accumulation levels of each identified compound were analyzed. Two flavonoid compounds, ligustroflavone and Morin, were identified with high content through quantitative analysis of the ion intensity. Conclusions: our data provides fundamental information for the protective utilization of T. cuspidata. Background: Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the leaves of T. cuspidata . However, the precise spatial distribution of active ingredients in the leaves of T. cuspidata is largely unknown. Results: in the present study, timsTOF flex MALDI-2 analysis was used to uncover the accumulation pattern of active ingredients in T. cuspidata leaves. In total, 3084 ion features were obtained, of which 944 were annotated according to the mass spectrometry database. The principal component analysis separated all of the detected metabolites into four typical leaf tissues: mesophyll cells, upper epidermis, lower epidermis, and vascular bundle cells. Imaging analysis identified several leaf tissues that specifically accumulated active ingredients, providing theoretical support for studying the regulation mechanism of compound biosynthesis. Furthermore, the relative accumulation levels of each identified compound were analyzed. Two flavonoid compounds, ligustroflavone and Morin, were identified with high content through quantitative analysis of the ion intensity. Conclusions: our data provides fundamental information for the protective utilization of T. cuspidata . |
| Author | Pei, Yanyan Li, Xiao-lin Zhan, Xiaori Shen, Chenjia Lin, Wanting Zang, Yue Ma, Ruoyun Jiang, Yan |
| AuthorAffiliation | Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants College of Life and Environmental Sciences Hangzhou Normal University College of Pharmacy State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica |
| AuthorAffiliation_xml | – name: State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica – name: Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants – name: College of Pharmacy – name: College of Life and Environmental Sciences – name: Hangzhou Normal University |
| Author_xml | – sequence: 1 givenname: Xiaori surname: Zhan fullname: Zhan, Xiaori organization: Hangzhou Normal University – sequence: 2 givenname: Yue surname: Zang fullname: Zang, Yue organization: Hangzhou Normal University – sequence: 3 givenname: Ruoyun surname: Ma fullname: Ma, Ruoyun organization: Hangzhou Normal University – sequence: 4 givenname: Wanting surname: Lin fullname: Lin, Wanting organization: Hangzhou Normal University – sequence: 5 givenname: Xiao-lin surname: Li fullname: Li, Xiao-lin organization: State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica – sequence: 6 givenname: Yanyan surname: Pei fullname: Pei, Yanyan organization: Hangzhou Normal University – sequence: 7 givenname: Chenjia orcidid: 0000-0002-8575-0593 surname: Shen fullname: Shen, Chenjia email: shencj@hznu.edu.cn organization: Hangzhou Normal University – sequence: 8 givenname: Yan surname: Jiang fullname: Jiang, Yan email: 840423924@qq.com organization: Hangzhou Normal University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38680336$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.phytochem.2019.112066 10.1016/j.phymed.2022.154223 10.1186/s40104-022-00742-y 10.3390/molecules24030412 10.1515/biol-2021-0032 10.1007/s00216-015-8460-5 10.1007/978-1-4939-7819-9_18 10.3390/molecules26154474 10.1021/jasms.1c00295 10.1016/j.indcrop.2023.117411 10.3389/fpls.2014.00362 10.1002/ptr.7501 10.1016/j.bbagen.2015.01.008 10.1016/j.jpba.2020.113456 10.1002/mc.23140 10.1111/tpj.14710 10.15625/7612 10.3389/fpls.2022.1012636 10.1111/jfbc.14502 10.1016/j.cbi.2022.109901 10.1016/j.xplc.2023.100630 10.1093/pcp/pcy149 10.1016/j.lfs.2018.08.074 10.3390/molecules28041713 10.1093/hr/uhac062 10.1016/j.scienta.2021.110762 10.1186/s12862-020-1582-1 10.1007/s10571-016-0405-9 10.1007/s10600-010-9523-7 10.1002/ptr.6613 10.3389/fchem.2023.1193188 10.7324/japs.2020.101210 10.7717/peerj.14391 10.1016/j.foodchem.2023.136101 10.3889/oamjms.2019.527 10.1021/acs.jnatprod.1c00980 10.1002/wsbm.1387 10.1016/j.phytochem.2008.01.002 10.3390/ijms24108516 10.1016/j.talanta.2024.125858 10.1021/np010053+ 10.1007/s10571-013-9939-2 10.1016/j.phytochem.2021.112930 10.1186/s12870-023-04308-6 10.5012/bkcs.2013.34.8.2507 10.1371/journal.pone.0184885 10.1111/jpi.12937 10.1186/1471-2105-16-s18-s7 10.1016/j.ejphar.2019.172699 10.1021/acs.analchem.8b02884 10.1093/treephys/tpad019 |
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| Snippet | Background: Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active... is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the... Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were... Background: Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active... |
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| Title | Mass Spectrometry-Imaging Analysis of Active Ingredients in the Leaves of Taxus cuspidata |
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