Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible Pseudomonas aeruginosa

• Published in: mSphere Vol. 6; no. 1
• Main Authors: Teo, Jocelyn Qi-Min, Lim, Jie Chong, Tang, Cheng Yee, Lee, Shannon Jing-Yi, Tan, Si Hui, Sim, James Heng-Chiak, Ong, Rick Twee-Hee, Kwa, Andrea Lay-Hoon
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 27.01.2021
• Subjects: Clinical Science and Epidemiology; Research Article; ceftolozane/tazobactam; Pseudomonas aeruginosa; molecular characterization

This study established the activity of ceftolozane/tazobactam (C/T) and its genotypic resistance mechanisms by whole-genome sequencing (WGS) in 195 carbapenem-nonsusceptible (CNSPA) clinical isolates recovered from Singapore between 2009 and 2020. C/T susceptibility rates were low, at 37.9%. Cross-r...