An Electrochemical Sensor for Quantitation of the Oral Health Care Agent Chlorogenic Acid Based on Bimetallic Nanowires with Functionalized Reduced Graphene Oxide Nanohybrids
Chlorogenic acid (CGA), a phenolic acid from coffee, has been regarded as a powerful ingredient against oxidative stress and inflammation. Meanwhile, its healing feature to interfere with periodontal disease (PD) makes it a promising drug candidate. However, the existing methods for chlorogenic acid...
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| Published in | ACS omega Vol. 7; no. 5; pp. 4614 - 4623 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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American Chemical Society
08.02.2022
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| Abstract | Chlorogenic acid (CGA), a phenolic acid from coffee, has been regarded as a powerful ingredient against oxidative stress and inflammation. Meanwhile, its healing feature to interfere with periodontal disease (PD) makes it a promising drug candidate. However, the existing methods for chlorogenic acid detection limit its practical application in purification and further pharmacological study in stomatology due to their lack of accuracy and productivity. Therefore, it is crucial to find a forceful approach to precisely evaluate CGA for an in-depth anti-PD study. In this work, we reported a facile and controllable synthesis of Pt@Pd nanowires (NWs) in a non-compacted core–shell structure with high electrocatalytic activity. In addition, polyethylenimine (PEI)-capped reduced graphene oxide (rGO) nanoflakes provided large binding sites for a network structure composed of interweaved Pt@Pd nanowires and protected hemin from self-destruction, which empowered Pt@Pd NWs-Hemin-PEI-rGO nanohybrids to own a large electroactive surface area and great electrochemical property for CGA detection. The enzyme-free electrochemical sensor based on Pt@Pd NWs-Hemin-PEI-rGO displayed a favorable capacity for trace CGA detection with a detection limit of 7.8 nM and a wide linear range of 0.5 μM to 4 mM. The exceptional sensitivity and selectivity of the sensor made it accomplish the measurements of chlorogenic acid in soft drinks and coffee with high consistency of HPLC results. The satisfactory performance of the obtained sensor enables it to be used for quality control and study of drug metabolism in PD treatments. |
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| AbstractList | Chlorogenic acid
(CGA), a phenolic acid from coffee, has been regarded
as a powerful ingredient against oxidative stress and inflammation.
Meanwhile, its healing feature to interfere with periodontal disease
(PD) makes it a promising drug candidate. However, the existing methods
for chlorogenic acid detection limit its practical application in
purification and further pharmacological study in stomatology due
to their lack of accuracy and productivity. Therefore, it is crucial
to find a forceful approach to precisely evaluate CGA for an in-depth
anti-PD study. In this work, we reported a facile and controllable
synthesis of Pt@Pd nanowires (NWs) in a non-compacted core–shell
structure with high electrocatalytic activity. In addition, polyethylenimine
(PEI)-capped reduced graphene oxide (rGO) nanoflakes provided large
binding sites for a network structure composed of interweaved Pt@Pd
nanowires and protected hemin from self-destruction, which empowered
Pt@Pd NWs-Hemin-PEI-rGO nanohybrids to own a large electroactive surface
area and great electrochemical property for CGA detection. The enzyme-free
electrochemical sensor based on Pt@Pd NWs-Hemin-PEI-rGO displayed
a favorable capacity for trace CGA detection with a detection limit
of 7.8 nM and a wide linear range of 0.5 μM to 4 mM. The exceptional
sensitivity and selectivity of the sensor made it accomplish the measurements
of chlorogenic acid in soft drinks and coffee with high consistency
of HPLC results. The satisfactory performance of the obtained sensor
enables it to be used for quality control and study of drug metabolism
in PD treatments. Chlorogenic acid (CGA), a phenolic acid from coffee, has been regarded as a powerful ingredient against oxidative stress and inflammation. Meanwhile, its healing feature to interfere with periodontal disease (PD) makes it a promising drug candidate. However, the existing methods for chlorogenic acid detection limit its practical application in purification and further pharmacological study in stomatology due to their lack of accuracy and productivity. Therefore, it is crucial to find a forceful approach to precisely evaluate CGA for an in-depth anti-PD study. In this work, we reported a facile and controllable synthesis of Pt@Pd nanowires (NWs) in a non-compacted core-shell structure with high electrocatalytic activity. In addition, polyethylenimine (PEI)-capped reduced graphene oxide (rGO) nanoflakes provided large binding sites for a network structure composed of interweaved Pt@Pd nanowires and protected hemin from self-destruction, which empowered Pt@Pd NWs-Hemin-PEI-rGO nanohybrids to own a large electroactive surface area and great electrochemical property for CGA detection. The enzyme-free electrochemical sensor based on Pt@Pd NWs-Hemin-PEI-rGO displayed a favorable capacity for trace CGA detection with a detection limit of 7.8 nM and a wide linear range of 0.5 μM to 4 mM. The exceptional sensitivity and selectivity of the sensor made it accomplish the measurements of chlorogenic acid in soft drinks and coffee with high consistency of HPLC results. The satisfactory performance of the obtained sensor enables it to be used for quality control and study of drug metabolism in PD treatments. Chlorogenic acid (CGA), a phenolic acid from coffee, has been regarded as a powerful ingredient against oxidative stress and inflammation. Meanwhile, its healing feature to interfere with periodontal disease (PD) makes it a promising drug candidate. However, the existing methods for chlorogenic acid detection limit its practical application in purification and further pharmacological study in stomatology due to their lack of accuracy and productivity. Therefore, it is crucial to find a forceful approach to precisely evaluate CGA for an in-depth anti-PD study. In this work, we reported a facile and controllable synthesis of Pt@Pd nanowires (NWs) in a non-compacted core-shell structure with high electrocatalytic activity. In addition, polyethylenimine (PEI)-capped reduced graphene oxide (rGO) nanoflakes provided large binding sites for a network structure composed of interweaved Pt@Pd nanowires and protected hemin from self-destruction, which empowered Pt@Pd NWs-Hemin-PEI-rGO nanohybrids to own a large electroactive surface area and great electrochemical property for CGA detection. The enzyme-free electrochemical sensor based on Pt@Pd NWs-Hemin-PEI-rGO displayed a favorable capacity for trace CGA detection with a detection limit of 7.8 nM and a wide linear range of 0.5 μM to 4 mM. The exceptional sensitivity and selectivity of the sensor made it accomplish the measurements of chlorogenic acid in soft drinks and coffee with high consistency of HPLC results. The satisfactory performance of the obtained sensor enables it to be used for quality control and study of drug metabolism in PD treatments.Chlorogenic acid (CGA), a phenolic acid from coffee, has been regarded as a powerful ingredient against oxidative stress and inflammation. Meanwhile, its healing feature to interfere with periodontal disease (PD) makes it a promising drug candidate. However, the existing methods for chlorogenic acid detection limit its practical application in purification and further pharmacological study in stomatology due to their lack of accuracy and productivity. Therefore, it is crucial to find a forceful approach to precisely evaluate CGA for an in-depth anti-PD study. In this work, we reported a facile and controllable synthesis of Pt@Pd nanowires (NWs) in a non-compacted core-shell structure with high electrocatalytic activity. In addition, polyethylenimine (PEI)-capped reduced graphene oxide (rGO) nanoflakes provided large binding sites for a network structure composed of interweaved Pt@Pd nanowires and protected hemin from self-destruction, which empowered Pt@Pd NWs-Hemin-PEI-rGO nanohybrids to own a large electroactive surface area and great electrochemical property for CGA detection. The enzyme-free electrochemical sensor based on Pt@Pd NWs-Hemin-PEI-rGO displayed a favorable capacity for trace CGA detection with a detection limit of 7.8 nM and a wide linear range of 0.5 μM to 4 mM. The exceptional sensitivity and selectivity of the sensor made it accomplish the measurements of chlorogenic acid in soft drinks and coffee with high consistency of HPLC results. The satisfactory performance of the obtained sensor enables it to be used for quality control and study of drug metabolism in PD treatments. |
| Author | Jiao, Jian Li, Wei Deng, Xiuli Zhang, Louqiang Wu, Ziyu |
| AuthorAffiliation | Tianjin Beichen Traditional Chinese Medicine Hospital Department of Stomatology School of Dentistry, Stomatological Hospital |
| AuthorAffiliation_xml | – name: Department of Stomatology – name: School of Dentistry, Stomatological Hospital – name: Tianjin Beichen Traditional Chinese Medicine Hospital |
| Author_xml | – sequence: 1 givenname: Wei surname: Li fullname: Li, Wei organization: Department of Stomatology – sequence: 2 givenname: Xiuli surname: Deng fullname: Deng, Xiuli organization: Tianjin Beichen Traditional Chinese Medicine Hospital – sequence: 3 givenname: Ziyu surname: Wu fullname: Wu, Ziyu organization: Tianjin Beichen Traditional Chinese Medicine Hospital – sequence: 4 givenname: Louqiang surname: Zhang fullname: Zhang, Louqiang organization: Department of Stomatology – sequence: 5 givenname: Jian orcidid: 0000-0001-6002-7297 surname: Jiao fullname: Jiao, Jian email: Jiaojian1985@tmu.edu.cn organization: School of Dentistry, Stomatological Hospital |
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| Title | An Electrochemical Sensor for Quantitation of the Oral Health Care Agent Chlorogenic Acid Based on Bimetallic Nanowires with Functionalized Reduced Graphene Oxide Nanohybrids |
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