Single-Molecule Investigation of the Binding Interface Stability of SARS-CoV‑2 Variants with ACE2

• Published in: ACS Nanoscience Au Vol. 4; no. 2; pp. 136 - 145
• Main Authors: Ray, Ankita, Minh Tran, Thu Thi, Santos Natividade, Rita dos, Moreira, Rodrigo A., Simpson, Joshua D., Mohammed, Danahe, Koehler, Melanie, L Petitjean, Simon J., Zhang, Qingrong, Bureau, Fabrice, Gillet, Laurent, Poma, Adolfo B., Alsteens, David
• Format: Journal Article Web Resource
• Language: English
• Published: United States American Chemical Society 17.04.2024; American Chemical Society (ACS)
• Subjects: ACE2; Atomic force microscopy; Biochemistry, Molecular Biology; biolayer interferometry; Biomechanics; Biophysics; Biotechnology; Chemical Sciences; Chemistry (miscellaneous); Computer Science; convalescent patient sera; Human health sciences; Immunologie & maladie infectieuse; Immunology & infectious disease; Life Sciences; Materials Science (miscellaneous); Mechanics; Modeling and Simulation; Physics; RBD; SARS-CoV-2; Sciences de la santé humaine; Steered molecular dynamics; ACE2; Atomic force microscopy; SARS-CoV-2; RBD; biolayer interferometry; Steered molecular dynamics; convalescent patient sera; SARS-CoV-2 ACE2 RBD Atomic force microscopy Steered molecular dynamics biolayer interferometry convalescent patient sera

The SARS-CoV-2 pandemic spurred numerous research endeavors to comprehend the virus and mitigate its global severity. Understanding the binding interface between the virus and human receptors is pivotal to these efforts and paramount to curbing infection and transmission. Here we employ atomic force...