Shortened Penetratin Cell-Penetrating Peptide Is Insufficient for Cytosolic Delivery of a Grb7 Targeting Peptide

• Published in: ACS omega Vol. 2; no. 2; pp. 670 - 677
• Main Authors: Watson, Gabrielle M, Kulkarni, Ketav, Brandt, Rebecca, Del Borgo, Mark P, Aguilar, Marie-Isabel, Wilce, Jacqueline A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.02.2017

Delivery across the cell membrane is of critical importance for the development of therapeutics targeting intracellular proteins. The use of cell-penetrating peptides (CPPs), such as Penetratin (P16), has facilitated the delivery of otherwise cell-impermeable molecules allowing them to carry out the...