Graphene as a Novel Matrix for the Analysis of Small Molecules by MALDI-TOF MS

• Published in: Analytical chemistry (Washington) Vol. 82; no. 14; pp. 6208 - 6214
• Main Authors: Dong, Xiaoli, Cheng, Jinsheng, Li, Jinghong, Wang, Yinsheng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.07.2010
• Subjects: Amino acids; Amino Acids - analysis; Analytical chemistry; Antineoplastic Agents - analysis; Carbon - chemistry; Desorption; Ionization; Irradiation; Mass spectrometry; Molecular weight; Nucleosides - analysis; Polyamines - analysis; Salt tolerance; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Steroids

Graphene was utilized for the first time as a matrix for the analysis of low molecular weight compounds using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Polar compounds including amino acids, polyamines, anticancer drugs, and nucleosides could be suc...