Enhanced efficacy of liposome-encapsulated ribavirin against Rift Valley fever virus infection in mice
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commerc...
Saved in:
| Published in | Antimicrobial Agents and Chemotherapy Vol. 27; no. 6; pp. 903 - 907 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Society for Microbiology
01.06.1985
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Classifications
Services
AAC
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley
Reddit
StumbleUpon
Twitter
current issue
AAC
About
AAC
Subscribers
Authors
Reviewers
Advertisers
Inquiries from the Press
Permissions & Commercial Reprints
ASM Journals Public Access Policy
AAC
RSS Feeds
1752 N Street N.W. • Washington DC 20036
202.737.3600 • 202.942.9355 fax • journals@asmusa.org
Print ISSN:
0066-4804
Online ISSN:
1098-6596
Copyright © 2014
by the
American Society for Microbiology.
For an alternate route to
AAC
.asm.org, visit:
AAC
|
|---|---|
| AbstractList | Administration of liposome-encapsulated ribavirin to mice led to ribavirin concentrations in the liver, the primary site of Rift Valley fever virus proliferation, that were fivefold greater than those attained with the same doses of free ribavirin. Liposomal ribavirin given at a dose of either 25 or 50 mg of drug per kg of body weight protected mice against a rapidly lethal high-titer challenge with Rift Valley fever virus, whereas similar doses of free drug or empty liposomes had no detectable benefit. Hence, tissue targeting of ribavirin with liposomes substantially increased the therapeutic index by increasing the efficacy of the treatment. By using liposomes as drug carriers, a nontoxic, low-dose regimen of ribavirin had a therapeutic effect that was comparable to that achieved with higher but potentially more toxic doses of free ribavirin. Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC Administration of liposome-encapsulated ribavirin to mice led to ribavirin concentrations in the liver, the primary site of Rift Valley fever virus proliferation, that were fivefold greater than those attained with the same doses of free ribavirin. Liposomal ribavirin given at a dose of either 225 or 50 mg of drug per kg of body weight protected mice against a rapidly lethal high-titer challenge with Rift Valley fever virus, whereas similar doses of free drug or empty liposomes had no detectable benefit. Hence, tissue targeting of ribavirin with liposomes substantially increased the therapeutic indix by increasing the efficacy of the treatment. By using liposomes as drug carriers, a nontoxic, low-dose regimen of ribavirin had a therapeutic effect that was comparable to that achieved with higher but potentially more toxic doses of free ribavirin. |
| Author | C R Alving P G Canonico M Kende W L Rill G M Swartz Jr |
| Author_xml | – sequence: 1 givenname: M surname: KENDE fullname: KENDE, M organization: Fort Detrick, US Army medical res. inst. infectious diseases – sequence: 2 givenname: C. R surname: ALVING fullname: ALVING, C. R organization: Fort Detrick, US Army medical res. inst. infectious diseases – sequence: 3 givenname: W. L surname: RILL fullname: RILL, W. L organization: Fort Detrick, US Army medical res. inst. infectious diseases – sequence: 4 givenname: G. M. JR surname: SWARTZ fullname: SWARTZ, G. M. JR organization: Fort Detrick, US Army medical res. inst. infectious diseases – sequence: 5 givenname: P. G surname: CANONICO fullname: CANONICO, P. G organization: Fort Detrick, US Army medical res. inst. infectious diseases |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8448104$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/4026264$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kUFrGzEQhUVJSJ20t14LOpRCoOtKWq1299CDMUlbCBRK26sYa0e2wq7kSrsO_vdRauO2h5xGw_tmHqN3Sc588EjIG87mnIvm42KxnIt6ruYtK1-QGWdtU6iqVWdkxphShWyYfEkuU7pnua9adkEuJBNKKDkj9sZvwBvsKFrrDJg9DZb2bhtSGLBAb2Cbph7GTES3gp2LzlNYg_NppN-dHekv6HvcU4s7jDTrU6LOWzSjCz6_6OAMviLnFvqEr4_1ivy8vfmx_FLcffv8dbm4K0C29Vh0HATrVh0XEoRlBpUpS1WWvBWMQckU8JKLGiuDVtZKGcU5Q1CVMI3teFVekU-HvdtpNWBn0I8Rer2NboC41wGc_l_xbqPXYad5w3hT5vn3x_kYfk-YRj24ZLDvwWOYkuaSK9X-MfpwAE0MKUW0Jw_O9FMsOseiRa2VzrFk_PqAQxqEvg9T9PkbnmPf_nvDafExs6y_O-qQDPQ25vxcOmGNlA1nTxg9YBu33jy4iDp7awDz1-kRZZKv9g |
| CODEN | AACHAX |
| CitedBy_id | crossref_primary_10_3390_ijms19113299 crossref_primary_10_1016_0005_2760_92_90238_Q crossref_primary_10_1177_095632029200300501 crossref_primary_10_3109_10717541003706257 crossref_primary_10_1016_S0264_410X_98_00439_3 crossref_primary_10_1016_S0264_410X_00_00450_3 crossref_primary_10_1097_00042560_199608150_00003 crossref_primary_10_1006_taap_1996_8080 crossref_primary_10_3109_10408418809104463 crossref_primary_10_3109_10717549509031363 crossref_primary_10_1002_hlca_201200203 crossref_primary_10_1016_j_bbrc_2016_08_050 crossref_primary_10_3109_02652048509033845 crossref_primary_10_1016_j_antiviral_2007_10_002 crossref_primary_10_1016_j_antiviral_2014_10_001 crossref_primary_10_3109_inf_1990_22_suppl_74_01 crossref_primary_10_3109_03639040903410342 crossref_primary_10_1016_0166_3542_93_90085_W crossref_primary_10_1111_j_1749_6632_1987_tb45797_x crossref_primary_10_1016_0034_5288_93_90076_R crossref_primary_10_1177_095632029200300601 crossref_primary_10_1186_s12985_016_0573_8 crossref_primary_10_1016_j_ddtec_2016_09_003 crossref_primary_10_1089_aid_1994_10_1463 crossref_primary_10_1177_135965359800300201 crossref_primary_10_1007_BF02389881 crossref_primary_10_1007_BF01644088 crossref_primary_10_3390_microorganisms10010092 crossref_primary_10_3109_08982109509039916 crossref_primary_10_1080_10611860500285439 crossref_primary_10_1211_jpp_58_3_0005 crossref_primary_10_2217_fvl_2017_0060 crossref_primary_10_1007_s10847_005_0170_8 crossref_primary_10_1007_s12275_017_7029_8 crossref_primary_10_1186_s12941_020_0346_5 crossref_primary_10_1371_journal_pntd_0002790 crossref_primary_10_1016_j_colsurfb_2014_09_029 crossref_primary_10_1016_j_nano_2016_01_021 crossref_primary_10_1016_S0022_5193_89_80147_X crossref_primary_10_1016_0166_3542_95_00003_5 crossref_primary_10_1016_0169_409X_95_00037_8 crossref_primary_10_1016_j_jconrel_2015_04_016 crossref_primary_10_1007_BF01875551 crossref_primary_10_1007_BF01639742 crossref_primary_10_2217_fvl_13_117 crossref_primary_10_1371_journal_pntd_0002156 crossref_primary_10_3109_10611869408996811 |
| ContentType | Journal Article |
| Copyright | 1986 INIST-CNRS |
| Copyright_xml | – notice: 1986 INIST-CNRS |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7U9 H94 5PM |
| DOI | 10.1128/AAC.27.6.903 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Virology and AIDS Abstracts AIDS and Cancer Research Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Virology and AIDS Abstracts |
| DatabaseTitleList | MEDLINE CrossRef AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology Biology |
| EISSN | 1098-6596 |
| EndPage | 907 |
| ExternalDocumentID | 10_1128_AAC_27_6_903 10.1128/AAC.27.6.903 4026264 8448104 aac_27_6_903 |
| Genre | Journal Article |
| GroupedDBID | --- .55 .GJ 08R 0R~ 23M 2WC 39C 3O- 4.4 53G 5GY 5RE 5VS 6J9 AAPBV AAUGY ACGFO ADBBV AENEX AFMIJ AGNAY AI. ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C1A CS3 DIK E3Z EBS EJD F5P FRP GX1 H13 HH5 HYE HZ~ H~9 IQODW J5H K-O KQ8 L7B LSO MVM NEJ O9- OK1 P2P RHF RHI RNS RPM RSF TR2 UHB VH1 W2D W8F WH7 WHG WOQ X7M X7N XOL Y6R ZA5 ZGI ZXP ~A~ AGVNZ CGR CUY CVF ECM EIF NPM - 0R 55 A ABFLS ADACO ADBIT BXI GJ HZ AAYXX CITATION 7U9 H94 5PM |
| ID | FETCH-LOGICAL-a497t-d1a20dbd124a2f0ce6c3363319200a306a13127e5cef4766c6110ea652c8fd153 |
| IEDL.DBID | RPM |
| ISSN | 0066-4804 |
| IngestDate | Tue Sep 17 21:25:24 EDT 2024 Thu Oct 24 22:34:34 EDT 2024 Thu Sep 12 17:07:22 EDT 2024 Tue Dec 28 13:58:58 EST 2021 Sat Sep 28 08:36:31 EDT 2024 Sun Oct 29 17:09:34 EDT 2023 Wed May 18 15:28:52 EDT 2016 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Therapeutic efficiency Encapsulation Transportation system Liver Rodentia Liposome Rift valley fever virus Infection Virus Vertebrata Chemotherapy Mammalia Bunyaviridae Mouse Animal Viral disease Antiviral Phlebovirus |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a497t-d1a20dbd124a2f0ce6c3363319200a306a13127e5cef4766c6110ea652c8fd153 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://europepmc.org/articles/pmc180183?pdf=render |
| PMID | 4026264 |
| PQID | 14166915 |
| PQPubID | 23462 |
| PageCount | 5 |
| ParticipantIDs | pubmed_primary_4026264 pascalfrancis_primary_8448104 highwire_asm_aac_27_6_903 proquest_miscellaneous_14166915 crossref_primary_10_1128_AAC_27_6_903 pubmedcentral_primary_oai_pubmedcentral_nih_gov_180183 asm2_journals_10_1128_AAC_27_6_903 |
| PublicationCentury | 1900 |
| PublicationDate | 19850601 |
| PublicationDateYYYYMMDD | 1985-06-01 |
| PublicationDate_xml | – month: 6 year: 1985 text: 19850601 day: 1 |
| PublicationDecade | 1980 |
| PublicationPlace | Washington, DC |
| PublicationPlace_xml | – name: Washington, DC – name: United States |
| PublicationTitle | Antimicrobial Agents and Chemotherapy |
| PublicationTitleAlternate | Antimicrob Agents Chemother |
| PublicationYear | 1985 |
| Publisher | American Society for Microbiology |
| Publisher_xml | – name: American Society for Microbiology |
| SSID | ssj0006590 |
| Score | 1.4876986 |
| Snippet | Classifications
Services
AAC
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley
Reddit... Administration of liposome-encapsulated ribavirin to mice led to ribavirin concentrations in the liver, the primary site of Rift Valley fever virus... |
| SourceID | pubmedcentral proquest crossref asm2 pubmed pascalfrancis highwire |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 903 |
| SubjectTerms | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Female Injections, Intravenous Liposomes Liposomes - administration & dosage Medical sciences Mice Pharmacology. Drug treatments Research Article Ribavirin Ribavirin - administration & dosage Ribavirin - metabolism Ribavirin - therapeutic use Ribonucleosides Ribonucleosides - therapeutic use Rift Valley Fever Rift Valley Fever - drug therapy Rift Valley fever virus Time Factors Tissue Distribution |
| Title | Enhanced efficacy of liposome-encapsulated ribavirin against Rift Valley fever virus infection in mice |
| URI | http://aac.asm.org/content/27/6/903.abstract https://www.ncbi.nlm.nih.gov/pubmed/4026264 https://journals.asm.org/doi/10.1128/AAC.27.6.903 https://search.proquest.com/docview/14166915 https://pubmed.ncbi.nlm.nih.gov/PMC180183 |
| Volume | 27 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9tAEB3qQEoupXUbqrZJl9LmFNnSSlpJR2MSQouLW5KSm1itVo3AkoxlB_zv8_TlxKW99CYYrZA0X292384SfU5CpCFUbGbsSG26vtJmgKxnBjGSFxAykmA9NTD7Lq5u3K-33m23KazqaJWFirNRschHRXbXcCuXuRr3PLHxfDa1EVYDZzygAeyzr9C76Cu8dl4FqdR0A8vtye48GE8m0xH3R2IUWs4RHaJyApqvu5rKKuf7eanvFVxTJWWFv5W2x1z8DYf-Sad8kp8uX9KLDliySfsBr-iZLoZ02B41uR3S81m3iD6ks3nbrnp7zq4fd19V5-yMzR8bWW9fU3pR3DUEAabrRhMYwcqULbJlWZW5NmHfEjX2Amg1YasslvfZKiuY_C0zYE72M0vX7Fd9VMuWpRoewyDfVKynfxW4Yjni1Bu6uby4nl6Z3bkMpnRDf20mtuRWEieABpKnltJCOY5w4MxwOYkaRNqOzX3tKZ26vhBKAGNoKTyugjRBiD2mg6Is9Ftiyk_cxPd1qgHcpCsRDhS3NBKI63IIDPpUKyfqHKuKmpqFBxF0GXE_EhF0adCXXnXRsu3R8Y_7jF6vEZ4aSameyE72FL17UID6FSWrQR97xUdwwHpVRRa63OCNAGlFaHsGHbdmsBvaGZhBYs8-dvK6s_e-BAbfdPhuDfzd_w58T0d2GHgto-0DHaxXG30C7LSOT2nw7Udw2rjMA_F1GIo |
| link.rule.ids | 230,315,730,783,787,888,27936,27937,53804,53806 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9NAEB1BUaEXPkIrDJSuEPRUO_HX2jlGUasATRWhBPW2Wq_X1CJ2ojhBCr-e59hOmwoOcIs0WSt23sy8sZ_fEn2Iu2hDmNjMyJXa9AKlzRBdzwwjNC8wZDTB8tbA8IoPJt7na_-6fimsqGWVuYpSK59mVp7ebLSV80y1G51YezTs2yirodt-SI-Qrh2vmdHr-sv96s4KmqnpIdzI3Z2w3ev1LSewuNXtuAe0j9kJfL70NZVF5ux2psYtuBRLygLXK6k2uvgTE70vqLzToS6e0aQ5t0qY8sNaLSNL_bpn-_ivJ_-cntaUlfWq6At6oPMW7VebWK5b9HhYP55v0emoMsJen7Hx7XtdxRk7ZaNbi-z1S0rO85uN9IDp0sICK9gsYdN0PitmmTaRORLT-xQ8OGaLNJI_00WaM_ldpmCz7GuaLNm3chOYNUs0cpEhvipYIyzL8YllqICHNLk4H_cHZr3jgym9brA0Y1s6nTiKQTqkk3SU5sp1uYsygWSWmG6k7dpOoH2lEy_gXHGwFy2576gwiVG8j2gvn-X6FTEVxF4cBDrRoITSkyg0yulotCbPcxAw6H35p4s6ZQuxmYacUAAjwgkEF8CIQR8bSIh55f7xl-8ZDV4EjiqkVHdixzsA2h4oxGSMYdigkwZQAqldPq-RuZ6t8ItAlnnX9g06quC1XVoD1yC-g7ttvPQM340ATRvv8Ao9r_934Qk9GYyHl-Ly09WXN3Rgd0O_0s29pb3lYqWPwdCW0btNQv4GNCA5Tw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9NAEB2Vola9FAhUuFC6QtBT_bW21_YxCo3KR6oItaicVuv1urWI7Sh2kMKvZ_yVNhVceos0Xitx3sy8sZ_fAnyIQ2xDOLHpkSOU7vpS6QF2PT2IsHkhQ8YmWN8amFyw8yv3y7V3vQVB_y5MI9qXUWrks8zI09tGWznPpNnrxMzpZGRjWQ0ccx4n5hN4iilrsX5O72ow89q7K9hQdTew3F7yTgNzOBwZ1DeYEVrOHuzg_IScvvY2FWVGN7tT7xhcCyZFidcsaTe7-BcbfSiqvNelxs_gZ__7WnHKL2NZRYb888D68TEX4Dnsd9SVDNsjXsCWygew025muRrA7qR7TD-Ak2lriL06JZd373eVp-SETO-sslcvITnLbxsJAlG1lQWuIEVCZum8KItM6ZhBAqf4GfLhmCzSSPxOF2lOxI1IkdWS72lSkR_1ZjArkijMSYLxZUl6gVmOn0iGlfAVXI3PLkfnerfzgy7c0K_02BbUiqMYyYegiSUVk47DHCwXmNQCpxxhOzb1lSdV4vqMSYYsRgnmURkkMRbxA9jOi1y9BiL92I19XyUKqaFwBRYcSS2FLcp1KQY0eF__8bxL3ZI3UxENOOKEU58zjjjR4GMPCz5vXUD-c5zWY4bjWbkQ8l7saANE6xMFOCHjUKzBcQ8qjileP7cRuSqW-I2QNLPQ9jQ4aCG2XtqBVwO2gb11vPYO34wgohoP8RZBh49deAy7009j_u3zxdc3sGeHgdfK597CdrVYqiMkalX0rsnJv_goO88 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Enhanced+efficacy+of+liposome-encapsulated+ribavirin+against+Rift+Valley+fever+virus+infection+in+mice&rft.jtitle=Antimicrobial+Agents+and+Chemotherapy&rft.au=M+Kende&rft.au=C+R+Alving&rft.au=W+L+Rill&rft.au=G+M+Swartz+Jr&rft.date=1985-06-01&rft.pub=American+Society+for+Microbiology&rft.issn=0066-4804&rft.eissn=1098-6596&rft.volume=27&rft.issue=6&rft.spage=903&rft_id=info:doi/10.1128%2FAAC.27.6.903&rft_id=info%3Apmid%2F4026264&rft.externalDBID=n%2Fa&rft.externalDocID=aac_27_6_903 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0066-4804&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0066-4804&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0066-4804&client=summon |