Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells

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Published inAntimicrobial Agents and Chemotherapy Vol. 26; no. 3; pp. 283 - 288
Main Authors Cheng, Y C, Grill, S P, Dutschman, G E, Frank, K B, Chiou, J F, Bastow, K F, Nakayama, K
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.1984
Subjects
Acyclovir
Acyclovir - analogs & derivatives
Acyclovir - metabolism
Acyclovir - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Antiviral Agents - pharmacology
Biological and medical sciences
Deoxyribonucleotides - analysis
DNA, Viral - biosynthesis
Enzyme Induction - drug effects
Ganciclovir
herpes simplex virus 1
herpes simplex virus 2
Humans
Medical sciences
Pharmacology. Drug treatments
Research Article
RNA, Viral - biosynthesis
Simplexvirus
Simplexvirus - drug effects
Simplexvirus - metabolism
Viral Proteins - biosynthesis
Virus
Macromolecule
Herpesviridae
Antiviral
DNA synthesis
Inhibition
Mechanism of action
In vitro
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Abstract Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
AbstractList We examined the effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on viral DNA, RNA, protein, and enzyme synthesis in HeLa cells infected with herpes simplex virus type 1 and type 2. DHPG inhibited virus DNA synthesis in a dose-dependent fashion. This inhibition was not due to the lack of deoxynucleoside triphosphates which are required for DNA synthesis. This compound has no apparent effect on early and late viral RNA synthesis, viral protein synthesis, or viral thymidine kinase, DNA polymerase, and DNase induction in virus-infected cells.
The authors examined the effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on viral DNA, RNA, protein, and enzyme synthesis in HeLa cells infected with herpes simplex virus type 1 and type 2. DHPG inhibited virus DNA synthesis in a dose-dependent fashion. This inhibition was not due to the lack of deoxynucleoside triphosphates which are required for DNA synthesis. This compound has no apparent effect on early and late viral RNA synthesis, viral protein synthesis, or viral thymidine kinase, DNA polymerase, and DNase induction in virus-infected cells.
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Author S P Grill
J F Chiou
K B Frank
Y C Cheng
G E Dutschman
K Nakayama
K F Bastow
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Snippet Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
We examined the effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on viral DNA, RNA, protein, and enzyme synthesis in HeLa cells infected with herpes...
The authors examined the effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on viral DNA, RNA, protein, and enzyme synthesis in HeLa cells infected with...
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SubjectTerms Acyclovir
Acyclovir - analogs & derivatives
Acyclovir - metabolism
Acyclovir - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Antiviral Agents - pharmacology
Biological and medical sciences
Deoxyribonucleotides - analysis
DNA, Viral - biosynthesis
Enzyme Induction - drug effects
Ganciclovir
herpes simplex virus 1
herpes simplex virus 2
Humans
Medical sciences
Pharmacology. Drug treatments
Research Article
RNA, Viral - biosynthesis
Simplexvirus
Simplexvirus - drug effects
Simplexvirus - metabolism
Viral Proteins - biosynthesis
Title Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells
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https://www.ncbi.nlm.nih.gov/pubmed/6095751
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Volume 26
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