Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study

• Published in: The American journal of psychiatry Vol. 173; no. 6; pp. 607 - 616
• Main Authors: Schnack, Hugo G., van Haren, Neeltje E.M., Nieuwenhuis, Mireille, Hulshoff Pol, Hilleke E., Cahn, Wiepke, Kahn, René S.
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.06.2016
• Subjects: Adolescent; Adult; Aged; Aging - pathology; Algorithms; Brain; Brain - pathology; Case-Control Studies; Disease Progression; Female; Gray Matter - pathology; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mental health care; Middle Aged; Models, Biological; Psychiatry; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - pathology; Support Vector Machine; Young Adult

Objective:Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a fundamentally different process? The authors used s...