Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin

• Published in: Organic letters Vol. 14; no. 22; pp. 5684 - 5687
• Main Authors: Guo, Chun-Jun, Knox, Benjamin P, Chiang, Yi-Ming, Lo, Hsien-Chun, Sanchez, James F, Lee, Kuan-Han, Oakley, Berl R, Bruno, Kenneth S, Wang, Clay C. C
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 16.11.2012; Amer Chemical Soc
• Subjects: Aspergillus nidulans - chemistry; Aspergillus nidulans - genetics; Aspergillus nidulans - metabolism; biosynthesis; chemical reactions; chemical structure; Chemistry; Chemistry, Organic; gene targeting; Molecular Structure; multigene family; mutants; Physical Sciences; polyketides; Science & Technology; Terpenes - chemistry; terpenoids; ASPERGILLUS-TERREUS; 3,5-DIMETHYLORSELLINATE; AUSTIN; METABOLITE

Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pat...