Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin

Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pat...

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Published inOrganic letters Vol. 14; no. 22; pp. 5684 - 5687
Main Authors Guo, Chun-Jun, Knox, Benjamin P, Chiang, Yi-Ming, Lo, Hsien-Chun, Sanchez, James F, Lee, Kuan-Han, Oakley, Berl R, Bruno, Kenneth S, Wang, Clay C. C
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 16.11.2012
Amer Chemical Soc
Subjects
Aspergillus nidulans - chemistry
Aspergillus nidulans - genetics
Aspergillus nidulans - metabolism
biosynthesis
chemical reactions
chemical structure
Chemistry
Chemistry, Organic
gene targeting
Molecular Structure
multigene family
mutants
Physical Sciences
polyketides
Science & Technology
Terpenes - chemistry
terpenoids
ASPERGILLUS-TERREUS
3,5-DIMETHYLORSELLINATE
AUSTIN
METABOLITE
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Abstract Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
AbstractList Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
Author Lee, Kuan-Han
Bruno, Kenneth S
Knox, Benjamin P
Guo, Chun-Jun
Lo, Hsien-Chun
Wang, Clay C. C
Oakley, Berl R
Sanchez, James F
Chiang, Yi-Ming
AuthorAffiliation University of Kansas
University of Southern California
Pacific Northwest National Laboratory
Chia Nan University of Pharmacy and Science
AuthorAffiliation_xml – name: University of Kansas
– name: Chia Nan University of Pharmacy and Science
– name: University of Southern California
– name: Pacific Northwest National Laboratory
– name: 4 Graduate Institute of Pharmaceutical Science, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan, ROC
– name: 5 Department of Chemistry, College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA 90089, USA
– name: 2 Chemical and Biological Process Development Group, Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA
– name: 1 Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
– name: 3 Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave., Lawrence, KS 66045, USA
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  fullname: Guo, Chun-Jun
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Snippet Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene...
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene...
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SubjectTerms Aspergillus nidulans - chemistry
Aspergillus nidulans - genetics
Aspergillus nidulans - metabolism
biosynthesis
chemical reactions
chemical structure
Chemistry
Chemistry, Organic
gene targeting
Molecular Structure
multigene family
mutants
Physical Sciences
polyketides
Science & Technology
Terpenes - chemistry
terpenoids
Title Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin
URI http://dx.doi.org/10.1021/ol302682z
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https://www.ncbi.nlm.nih.gov/pubmed/23116177
https://www.proquest.com/docview/1273246869
https://www.proquest.com/docview/2010197318
https://pubmed.ncbi.nlm.nih.gov/PMC3538129
Volume 14
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