Intestinal Absorption of Fructose
Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now constitutes a physiologically significant portion of human diets and is associated with increased incidence of certain cancers and metabolic diseases. New insights in our kno...
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| Published in | Annual review of nutrition Vol. 38; p. 41 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
21.08.2018
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now constitutes a physiologically significant portion of human diets and is associated with increased incidence of certain cancers and metabolic diseases. New insights in our knowledge of intestinal fructose absorption mediated by the facilitative glucose transporter GLUT5 in the apical membrane and by GLUT2 in the basolateral membrane are reviewed. We begin with studies related to structure as well as ligand binding, then revisit the controversial proposition that apical GLUT2 is the main mediator of intestinal fructose absorption. The review then describes how dietary fructose may be sensed by intestinal cells to affect the expression and activity of transporters and fructolytic enzymes, to interact with the transport of certain minerals and electrolytes, and to regulate portal and peripheral fructosemia and glycemia. Finally, it discusses the potential contributions of dietary fructose to gastrointestinal diseases and to the gut microbiome. |
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| AbstractList | Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now constitutes a physiologically significant portion of human diets and is associated with increased incidence of certain cancers and metabolic diseases. New insights in our knowledge of intestinal fructose absorption mediated by the facilitative glucose transporter GLUT5 in the apical membrane and by GLUT2 in the basolateral membrane are reviewed. We begin with studies related to structure as well as ligand binding, then revisit the controversial proposition that apical GLUT2 is the main mediator of intestinal fructose absorption. The review then describes how dietary fructose may be sensed by intestinal cells to affect the expression and activity of transporters and fructolytic enzymes, to interact with the transport of certain minerals and electrolytes, and to regulate portal and peripheral fructosemia and glycemia. Finally, it discusses the potential contributions of dietary fructose to gastrointestinal diseases and to the gut microbiome. |
| Author | Patel, Chirag R Ferraris, Ronaldo P Choe, Jun-Yong |
| Author_xml | – sequence: 1 givenname: Ronaldo P surname: Ferraris fullname: Ferraris, Ronaldo P email: ferraris@njms.rutgers.edu organization: Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, New Jersey 07946, USA; email: ferraris@njms.rutgers.edu – sequence: 2 givenname: Jun-Yong surname: Choe fullname: Choe, Jun-Yong email: junyong.choe@rosalindfranklin.edu organization: Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA; email: junyong.choe@rosalindfranklin.edu – sequence: 3 givenname: Chirag R surname: Patel fullname: Patel, Chirag R email: chirag.pharmacy@gmail.com organization: Independent Drug Safety Consulting, Wilmington, Delaware 19803, USA; email: chirag.pharmacy@gmail.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29751733$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Biological Transport Diet Fructose - metabolism Gene Expression Regulation Humans Intestines - physiology |
| Title | Intestinal Absorption of Fructose |
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