Dynamics of Soft Nanomaterials Captured by Transmission Electron Microscopy in Liquid Water

In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provi...

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Published inJournal of the American Chemical Society Vol. 136; no. 4; pp. 1162 - 1165
Main Authors Proetto, Maria T, Rush, Anthony M, Chien, Miao-Ping, Abellan Baeza, Patricia, Patterson, Joseph P, Thompson, Matthew P, Olson, Norman H, Moore, Curtis E, Rheingold, Arnold L, Andolina, Christopher, Millstone, Jill, Howell, Stephen B, Browning, Nigel D, Evans, James E, Gianneschi, Nathan C
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 29.01.2014
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Abstract In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.
AbstractList In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.
In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.
In this paper we present in situ transmission electron microscopy (TEM) of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ . We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.
Author Thompson, Matthew P
Gianneschi, Nathan C
Evans, James E
Abellan Baeza, Patricia
Patterson, Joseph P
Millstone, Jill
Rheingold, Arnold L
Howell, Stephen B
Chien, Miao-Ping
Moore, Curtis E
Andolina, Christopher
Browning, Nigel D
Proetto, Maria T
Olson, Norman H
Rush, Anthony M
AuthorAffiliation Department of Chemistry
University of Pittsburgh
Department of Chemistry & Biochemistry
Environmental Molecular Sciences Laboratory
University of California, San Diego
Fundamental Computational Sciences Directorate
Moores Cancer Center
Pacific Northwest National Laboratory
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– name: Pacific Northwest National Laboratory
– name: Moores Cancer Center
– name: Environmental Molecular Sciences Laboratory
– name: University of Pittsburgh
– name: 1 Department of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA 92093
– name: 5 Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354
– name: 4 Moores Cancer Center, University of California, San Diego, La Jolla CA 92093
– name: 3 Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260
– name: 2 Fundamental Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354
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  email: ngianneschi@ucsd.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24422495$$D View this record in MEDLINE/PubMed
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Snippet In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous...
In this paper we present in situ transmission electron microscopy (TEM) of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated,...
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SubjectTerms image analysis
Microscopy, Electron, Transmission
Models, Molecular
Molecular Structure
nanoparticles
Nanoparticles - chemistry
Particle Size
polymerization
Polymers - chemical synthesis
Polymers - chemistry
Surface Properties
Thermodynamics
transmission electron microscopy
Water - chemistry
Title Dynamics of Soft Nanomaterials Captured by Transmission Electron Microscopy in Liquid Water
URI http://dx.doi.org/10.1021/ja408513m
https://www.ncbi.nlm.nih.gov/pubmed/24422495
https://www.proquest.com/docview/1493801191
https://www.proquest.com/docview/2000413592
https://pubmed.ncbi.nlm.nih.gov/PMC4021868
Volume 136
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