Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis
Nanometric field-effect-transistor (FET) sensors are made on the tip of spear-shaped dual carbon nanoelectrodes derived from carbon deposition inside double-barrel nanopipettes. The easy fabrication route allows deposition of semiconductors or conducting polymers to comprise the transistor channel....
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Published in | ACS nano Vol. 10; no. 3; pp. 3214 - 3221 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
American Chemical Society
22.03.2016
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Abstract | Nanometric field-effect-transistor (FET) sensors are made on the tip of spear-shaped dual carbon nanoelectrodes derived from carbon deposition inside double-barrel nanopipettes. The easy fabrication route allows deposition of semiconductors or conducting polymers to comprise the transistor channel. A channel from electrodeposited poly pyrrole (PPy) exhibits high sensitivity toward pH changes. This property is exploited by immobilizing hexokinase on PPy nano-FETs to give rise to a selective ATP biosensor. Extracellular pH and ATP gradients are key biochemical constituents in the microenvironment of living cells; we monitor their real-time changes in relation to cancer cells and cardiomyocytes. The highly localized detection is possible because of the high aspect ratio and the spear-like design of the nano-FET probes. The accurately positioned nano-FET sensors can detect concentration gradients in three-dimensional space, identify biochemical properties of a single living cell, and after cell membrane penetration perform intracellular measurements. |
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AbstractList | Nanometric field-effect-transistor (FET) sensors are made on the tip of spear-shaped dual carbon nanoelectrodes derived from carbon deposition inside double-barrel nanopipettes. The easy fabrication route allows deposition of semiconductors or conducting polymers to comprise the transistor channel. A channel from electrodeposited poly pyrrole (PPy) exhibits high sensitivity toward pH changes. This property is exploited by immobilizing hexokinase on PPy nano-FETs to give rise to a selective ATP biosensor. Extracellular pH and ATP gradients are key biochemical constituents in the microenvironment of living cells; we monitor their real-time changes in relation to cancer cells and cardiomyocytes. The highly localized detection is possible because of the high aspect ratio and the spear-like design of the nano-FET probes. The accurately positioned nano-FET sensors can detect concentration gradients in three-dimensional space, identify biochemical properties of a single living cell, and after cell membrane penetration perform intracellular measurements. |
Author | Zhang, Yanjun Babakinejad, Babak Gopal, Sahana Chiappini, Ciro Takahashi, Yasufumi Anand, Uma Korchev, Yuri Coombes, R. Charles Klenerman, David López Córdoba, Ainara Novak, Pavel Lab, Max Sviderskaya, Elena V Clausmeyer, Jan Gorelik, Julia Magnani, Luca Ali, Tayyibah Matsue, Tomokazu Schuhmann, Wolfgang Shevchuk, Andrew Edwards, Christopher |
AuthorAffiliation | Division of Biomedical Sciences Analytical ChemistryCenter for Electrochemical Sciences (CES) Department of Cardiac Medicine, National Heart and Lung Institute Department of Medicine St. George’s University of London Imperial College London Advanced Institute for Materials Research Ruhr-Universität Bochum Tohoku University School of Engineering and Materials Science Department of Surgery and Cancer Department of Chemistry Queen Mary, University of London University of Cambridge Department of Materials |
AuthorAffiliation_xml | – name: Department of Cardiac Medicine, National Heart and Lung Institute – name: Analytical ChemistryCenter for Electrochemical Sciences (CES) – name: Department of Chemistry – name: Division of Biomedical Sciences – name: Department of Medicine – name: Imperial College London – name: Queen Mary, University of London – name: Department of Materials – name: University of Cambridge – name: Ruhr-Universität Bochum – name: – name: Advanced Institute for Materials Research – name: Tohoku University – name: St. George’s University of London – name: Department of Surgery and Cancer – name: School of Engineering and Materials Science – name: Analytical Chemistry—Center for Electrochemical Sciences (CES), Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany – name: Department of Surgery and Cancer, Imperial College London, London W12 0NN, United Kingdom – name: Department of Cardiac Medicine, National Heart and Lung Institute, London W12 0NN, United Kingdom – name: Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom – name: School of Engineering and Materials Science, Queen Mary, University of London, London E1 4NS, United Kingdom – name: Cell Biology and Genetics Research Centre, St. George's University of London, London SW17 0RE, United Kingdom – name: Department of Medicine, London W12 0NN, United Kingdom – name: Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan – name: Department of Materials, Imperial College London, London SW7 2AZ, United Kingdom |
Author_xml | – sequence: 1 givenname: Yanjun surname: Zhang fullname: Zhang, Yanjun – sequence: 2 givenname: Jan surname: Clausmeyer fullname: Clausmeyer, Jan – sequence: 3 givenname: Babak surname: Babakinejad fullname: Babakinejad, Babak – sequence: 4 givenname: Ainara surname: López Córdoba fullname: López Córdoba, Ainara – sequence: 5 givenname: Tayyibah surname: Ali fullname: Ali, Tayyibah – sequence: 6 givenname: Andrew surname: Shevchuk fullname: Shevchuk, Andrew – sequence: 7 givenname: Yasufumi surname: Takahashi fullname: Takahashi, Yasufumi – sequence: 8 givenname: Pavel surname: Novak fullname: Novak, Pavel – sequence: 9 givenname: Christopher surname: Edwards fullname: Edwards, Christopher – sequence: 10 givenname: Max surname: Lab fullname: Lab, Max – sequence: 11 givenname: Sahana surname: Gopal fullname: Gopal, Sahana – sequence: 12 givenname: Ciro surname: Chiappini fullname: Chiappini, Ciro – sequence: 13 givenname: Uma surname: Anand fullname: Anand, Uma – sequence: 14 givenname: Luca surname: Magnani fullname: Magnani, Luca – sequence: 15 givenname: R. Charles surname: Coombes fullname: Coombes, R. Charles – sequence: 16 givenname: Julia surname: Gorelik fullname: Gorelik, Julia – sequence: 17 givenname: Tomokazu surname: Matsue fullname: Matsue, Tomokazu – sequence: 18 givenname: Wolfgang surname: Schuhmann fullname: Schuhmann, Wolfgang email: wolfgang.schuhmann@rub.de – sequence: 19 givenname: David surname: Klenerman fullname: Klenerman, David email: dk10012@cam.ac.uk – sequence: 20 givenname: Elena V surname: Sviderskaya fullname: Sviderskaya, Elena V email: esviders@sgul.ac.uk – sequence: 21 givenname: Yuri surname: Korchev fullname: Korchev, Yuri email: y.korchev@imperial.ac.uk |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26816294$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Adenosine Triphosphate - analysis Adenosine Triphosphate - metabolism Biosensing Techniques - instrumentation Cell Line, Tumor Disulfides - chemistry Electrodes Enzymes, Immobilized - metabolism Equipment Design Hexokinase - metabolism Humans Molybdenum - chemistry Nanostructures - chemistry Nanostructures - ultrastructure Polymers - chemistry Pyrroles - chemistry Saccharomyces cerevisiae - enzymology Single-Cell Analysis - instrumentation Transistors, Electronic |
Title | Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis |
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