Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence

• Published in: Annual review of biophysics Vol. 46; p. 85
• Main Authors: Echave, Julian, Wilke, Claus O
• Format: Journal Article
• Language: English
• Published: United States 22.05.2017
• Subjects: Biophysical Phenomena; Biophysics; Evolution, Molecular; Genetic Fitness; Humans; Mutation; Protein Folding; Protein Stability; Proteins - chemistry; Proteins - genetics; Thermodynamics; protein–protein interaction; fitness landscape; protein folding; protein misfolding; evolutionary rate

For decades, rates of protein evolution have been interpreted in terms of the vague concept of functional importance. Slowly evolving proteins or sites within proteins were assumed to be more functionally important and thus subject to stronger selection pressure. More recently, biophysical models of...