Disrupted ventromedial prefrontal function, alcohol craving, and subsequent relapse risk

• Published in: JAMA psychiatry (Chicago, Ill.) Vol. 70; no. 7; p. 727
• Main Authors: Seo, Dongju, Lacadie, Cheryl M, Tuit, Keri, Hong, Kwang-Ik, Constable, R Todd, Sinha, Rajita
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Adolescent; Adult; Alcoholism - physiopathology; Alcoholism - psychology; Behavior, Addictive - physiopathology; Case-Control Studies; Corpus Striatum - physiopathology; Cues; Female; Functional Neuroimaging - psychology; Gyrus Cinguli - physiopathology; Humans; Male; Middle Aged; Prefrontal Cortex - physiopathology; Recurrence

Alcohol dependence is a chronic relapsing illness; stress, alcohol-related cues, and neutral-relaxing states significantly influence craving and relapse risk. However, neural mechanisms underlying the association between these states and alcohol craving and relapse risk remain unclear. To identify n...