Polymeric Biomaterials for Medical Implants and Devices

In this review article, we focus on the various types of materials used in biomedical implantable devices, including the polymeric materials used as substrates and for the packaging of such devices. Polymeric materials are used because of the ease of fabrication, flexibility, and their biocompatible...

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Published inACS biomaterials science & engineering Vol. 2; no. 4; pp. 454 - 472
Main Authors Teo, Adrian J.T, Mishra, Abhinay, Park, Inkyu, Kim, Young-Jin, Park, Woo-Tae, Yoon, Yong-Jin
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.04.2016
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Abstract In this review article, we focus on the various types of materials used in biomedical implantable devices, including the polymeric materials used as substrates and for the packaging of such devices. Polymeric materials are used because of the ease of fabrication, flexibility, and their biocompatible nature as well as their wide range of mechanical, electrical, chemical, and thermal behaviors when combined with different materials as composites. Biocompatible and biostable polymers are extensively used to package implanted devices, with the main criteria that include gas permeability and water permeability of the packaging polymer to protect the electronic circuit of the device from moisture and ions inside the human body. Polymeric materials must also have considerable tensile strength and should be able to contain the device over the envisioned lifetime of the implant. For substrates, structural properties and, at times, electrical properties would be of greater concern. Section gives an introduction of some medical devices and implants along with the material requirements and properties needed. Different synthetic polymeric materials such as polyvinylidene fluoride, polyethylene, polypropylene, polydimethylsiloxane, parylene, polyamide, polytetrafluoroethylene, poly­(methyl methacrylate), polyimide, and polyurethane have been examined, and liquid crystalline polymers and nanocomposites have been evaluated as biomaterials that are suitable for biomedical packaging (section ). A summary and glimpse of the future trend in this area has also been given (section ). Materials and information used in this manuscript are adapted from papers published between 2010 and 2015 representing the most updated information available on each material.
AbstractList In this review article, we focus on the various types of materials used in biomedical implantable devices, including the polymeric materials used as substrates and for the packaging of such devices. Polymeric materials are used because of the ease of fabrication, flexibility, and their biocompatible nature as well as their wide range of mechanical, electrical, chemical, and thermal behaviors when combined with different materials as composites. Biocompatible and biostable polymers are extensively used to package implanted devices, with the main criteria that include gas permeability and water permeability of the packaging polymer to protect the electronic circuit of the device from moisture and ions inside the human body. Polymeric materials must also have considerable tensile strength and should be able to contain the device over the envisioned lifetime of the implant. For substrates, structural properties and, at times, electrical properties would be of greater concern. Section gives an introduction of some medical devices and implants along with the material requirements and properties needed. Different synthetic polymeric materials such as polyvinylidene fluoride, polyethylene, polypropylene, polydimethylsiloxane, parylene, polyamide, polytetrafluoroethylene, poly­(methyl methacrylate), polyimide, and polyurethane have been examined, and liquid crystalline polymers and nanocomposites have been evaluated as biomaterials that are suitable for biomedical packaging (section ). A summary and glimpse of the future trend in this area has also been given (section ). Materials and information used in this manuscript are adapted from papers published between 2010 and 2015 representing the most updated information available on each material.
In this review article, we focus on the various types of materials used in biomedical implantable devices, including the polymeric materials used as substrates and for the packaging of such devices. Polymeric materials are used because of the ease of fabrication, flexibility, and their biocompatible nature as well as their wide range of mechanical, electrical, chemical, and thermal behaviors when combined with different materials as composites. Biocompatible and biostable polymers are extensively used to package implanted devices, with the main criteria that include gas permeability and water permeability of the packaging polymer to protect the electronic circuit of the device from moisture and ions inside the human body. Polymeric materials must also have considerable tensile strength and should be able to contain the device over the envisioned lifetime of the implant. For substrates, structural properties and, at times, electrical properties would be of greater concern. Section 1 gives an introduction of some medical devices and implants along with the material requirements and properties needed. Different synthetic polymeric materials such as polyvinylidene fluoride, polyethylene, polypropylene, polydimethylsiloxane, parylene, polyamide, polytetrafluoroethylene, poly(methyl methacrylate), polyimide, and polyurethane have been examined, and liquid crystalline polymers and nanocomposites have been evaluated as biomaterials that are suitable for biomedical packaging (section 2). A summary and glimpse of the future trend in this area has also been given (section 3). Materials and information used in this manuscript are adapted from papers published between 2010 and 2015 representing the most updated information available on each material.
Author Park, Woo-Tae
Kim, Young-Jin
Mishra, Abhinay
Park, Inkyu
Yoon, Yong-Jin
Teo, Adrian J.T
AuthorAffiliation Department of Mechanical and Automotive Engineering
Seoul National University of Science and Technology
Department of Mechanical Engineering
School of Mechanical & Aerospace Engineering
Nanyang Technological University
Korea Advanced Institute of Science and Technology (KAIST)
AuthorAffiliation_xml – name: Seoul National University of Science and Technology
– name: Korea Advanced Institute of Science and Technology (KAIST)
– name: Department of Mechanical Engineering
– name: School of Mechanical & Aerospace Engineering
– name: Department of Mechanical and Automotive Engineering
– name: Nanyang Technological University
Author_xml – sequence: 1
  givenname: Adrian J.T
  surname: Teo
  fullname: Teo, Adrian J.T
– sequence: 2
  givenname: Abhinay
  surname: Mishra
  fullname: Mishra, Abhinay
– sequence: 3
  givenname: Inkyu
  surname: Park
  fullname: Park, Inkyu
– sequence: 4
  givenname: Young-Jin
  surname: Kim
  fullname: Kim, Young-Jin
– sequence: 5
  givenname: Woo-Tae
  surname: Park
  fullname: Park, Woo-Tae
  email: wtpark@seoultech.ac.kr
– sequence: 6
  givenname: Yong-Jin
  surname: Yoon
  fullname: Yoon, Yong-Jin
  email: yongjiny@ntu.edu.sg
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33465850$$D View this record in MEDLINE/PubMed
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Snippet In this review article, we focus on the various types of materials used in biomedical implantable devices, including the polymeric materials used as substrates...
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Title Polymeric Biomaterials for Medical Implants and Devices
URI http://dx.doi.org/10.1021/acsbiomaterials.5b00429
https://www.ncbi.nlm.nih.gov/pubmed/33465850
https://search.proquest.com/docview/2479419220
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