Variability Analysis of Human Plasma and Cerebral Spinal Fluid Reveals Statistical Significance of Changes in Mass Spectrometry-Based Metabolomics Data - Crews, Bridgit; Wikoff, William R; Patti, Gary J; Woo, Hin-Koon; Kalisiak, Ewa; Heideker, Johanna; Siuzdak, Gary (Analytical chemistry (Washington), 2009)
Keywords: Analysis of Variance; Analytical chemistry; Biological analysis; Biological variation; Biomarkers - blood; Biomarkers - metabolism; Blood Chemical Analysis - methods; Cerebrospinal Fluid - chemistry; Cerebrospinal Fluid - metabolism; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography; Chromatography, Liquid; Coefficient of variation; Comparative analysis; Databases, Factual; Exact sciences and technology; Humans; Liquid chromatography; Mass spectra; Mass Spectrometry; Metabolites; Metabolomics; Nonlinear Dynamics; Other chromatographic methods; Plasma; Principal Component Analysis; Reproducibility of Results; Software; Spectrometric and optical methods; Human; Metabolomics; Peak resolution; Metabolite; Coupled method; Biological marker; Liquid chromatography; Retention time; Reproducibility; Mass spectrometry MS/MS; Robustness; Mass spectrometry; Variation coefficient