Brain SPECT Imaging of Amphetamine-Induced Dopamine Release in Euthymic Bipolar Disorder Patients

• Published in: The American journal of psychiatry Vol. 157; no. 7; pp. 1108 - 1114
• Main Authors: Anand, Amit, Verhoeff, Paul, Seneca, Nicholas, Zoghbi, Sami S., Seibyl, John P., Charney, Dennis S., Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.07.2000; American Psychiatric Association
• Subjects: Adult; Adult and adolescent clinical studies; Amphetamine - pharmacology; Amphetamines; Benzamides - metabolism; Biological and medical sciences; Bipolar Disorder - diagnostic imaging; Bipolar Disorder - metabolism; Bipolar Disorder - physiopathology; Bipolar disorders; Blood Pressure - drug effects; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain - physiopathology; Corpus Striatum - diagnostic imaging; Corpus Striatum - metabolism; Corpus Striatum - physiopathology; Dopamine - metabolism; Dopamine Antagonists - metabolism; Female; Heart Rate - drug effects; Humans; Iodine Radioisotopes - metabolism; Male; Manic depression; Medical imaging; Medical sciences; Mental disorders; Mood disorders; Neurotransmitters; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Pulse; Pyrrolidines - metabolism; Receptors, Dopamine - drug effects; Receptors, Dopamine - metabolism; Tomography, Emission-Computed, Single-Photon; Radionuclide study; Mood disorder; Amphetamine derivatives; Human; Dopamine; Pathophysiology; Induction; Central nervous system; Bipolar disorder; Photon; Dopaminergic transmission; Biological fixation; D2 Dopamine receptor; Amfetamine; Clinical investigation; Computer aid; Release; Brain (vertebrata); Emission tomography

OBJECTIVE: Increased dopaminergic neurotransmission has been implicated in the pathophysiology of bipolar disorder. However, it remains unclear whether the abnormality is due to increased dopamine release or enhanced postsynaptic receptor sensitivity. In this study, dopamine receptor imaging combine...