Multi-Scale Simulation of the Simian Immunodeficiency Virus Fusion Peptide

• Published in: The journal of physical chemistry. B Vol. 116; no. 46; pp. 13713 - 13721
• Main Authors: Crowet, Jean-Marc, Parton, Daniel L, Hall, Benjamin A, Steinhauer, Sven, Brasseur, Robert, Lins, Laurence, Sansom, Mark S. P
• Format: Journal Article Web Resource
• Language: English
• Published: United States American Chemical Society 26.11.2012
• Subjects: Biochemistry, biophysics & molecular biology; Biochimie, biophysique & biologie moléculaire; glycoproteins; Life Sciences; lipid bilayers; Lipid Bilayers - chemistry; Lipids; Mathematical analysis; Membranes; Models, Biological; Molecular Dynamics Simulation; mutants; Orientation; Peptides; Peptides - chemistry; physical chemistry; Quantitative Methods; Sampling; Sciences du vivant; Simian immunodeficiency virus; Simian Immunodeficiency Virus - chemistry; Simulation; Viral Fusion Proteins - chemistry; Viruses

Fusion peptides of type I fusion glycoproteins are structural elements of several enveloped viruses which enable the fusion between host and virus membranes. It is generally suggested that these peptides can promote the early fusion steps by inducing membrane curvature and that they adopt a tilted h...