Disrupted Reinforcement Signaling in the Orbitofrontal Cortex and Caudate in Youths With Conduct Disorder or Oppositional Defiant Disorder and a High Level of Psychopathic Traits

• Published in: The American journal of psychiatry Vol. 168; no. 2; pp. 152 - 162
• Main Authors: Finger, Elizabeth C., Marsh, Abigail A., Blair, Karina S., Reid, Marguerite E., Sims, Courtney, Ng, Pamela, Pine, Daniel S., Blair, R. James R.
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Publishing 01.02.2011; American Psychiatric Association
• Subjects: Adolescent; Adult and adolescent clinical studies; Amygdala - physiopathology; Antisocial Personality Disorder - diagnosis; Antisocial Personality Disorder - physiopathology; Antisocial Personality Disorder - psychology; Association Learning - physiology; Attention Deficit and Disruptive Behavior Disorders - diagnosis; Attention Deficit and Disruptive Behavior Disorders - physiopathology; Attention Deficit and Disruptive Behavior Disorders - psychology; Avoidance Learning - physiology; Behavior disorders; Biological and medical sciences; Brain; Brain Mapping; Caudate Nucleus - physiopathology; Child & adolescent psychiatry; Child clinical studies; Conduct disorder; Conduct Disorder - diagnosis; Conduct Disorder - physiopathology; Conduct Disorder - psychology; Decision making; Decision Making - physiology; Feedback, Psychological; Female; Frontal Lobe - physiopathology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Medical sciences; Mental health; Motivation; Nerve Net - physiopathology; Oxygen Consumption - physiology; Pattern Recognition, Visual - physiology; Personality disorders; Pharmacology; Psychology. Psychoanalysis. Psychiatry; Psychomotor Performance - physiology; Psychopathology; Psychopathology. Psychiatry; Reference Values; Reinforcement, Psychology; Signal Transduction - physiology; Social behavior disorders; Human; Orbitofrontal cortex; Oppositional defiant disorder; Central nervous system; Conduct disorder; Basal ganglion; Experimental study; Metabolism; Nuclear magnetic resonance imaging; Personality disorder; Encephalon; Learning; Signal transduction; Acquisition process; School age; Caudate nucleus; Psychopathia; Adolescent; Reinforcement; Social behavior disorder; Child; Avoidance; Functional imaging; Psychopathic personality

Objective:Dysfunction in the amygdala and orbitofrontal cortex has been reported in youths and adults with psychopathic traits. The specific nature of the functional irregularities within these structures remains poorly understood. The authors used a passive avoidance task to examine the responsiven...