PfHDAC1 is an essential regulator of P. falciparum asexual proliferation and host cell invasion genes with a dynamic genomic occupancy responsive to artemisinin stress

• Published in: mBio Vol. 15; no. 6; p. e0237723
• Main Authors: Kanyal, Abhishek, Deshmukh, Bhagyashree, Davies, Heledd, Mamatharani, D. V., Farheen, Dilsha, Treeck, Moritz, Karmodiya, Krishanpal
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 12.06.2024
• Subjects: Antimalarials - pharmacology; artemisinin resistance; Artemisinins - pharmacology; Erythrocytes - parasitology; histone deacetylase; Histone Deacetylase 1 - genetics; Histone Deacetylase 1 - metabolism; Humans; malaria; Malaria, Falciparum - parasitology; Parasitology; PfHDAC1; Plasmodium falciparum; Plasmodium falciparum - drug effects; Plasmodium falciparum - genetics; Plasmodium falciparum - growth & development; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Reproduction, Asexual - genetics; Research Article; transcriptomics; artemisinin resistance; transcriptomics; Plasmodium falciparum; PfHDAC1; malaria; histone deacetylase

Malaria is a major public health problem, with the parasite Plasmodium falciparum causing most of the malaria-associated mortality. It is spread by the bite of infected mosquitoes and results in symptoms such as cyclic fever, chills, and headache. However, if left untreated, it can quickly progress...