PfHDAC1 is an essential regulator of P. falciparum asexual proliferation and host cell invasion genes with a dynamic genomic occupancy responsive to artemisinin stress - Kanyal, Abhishek; Deshmukh, Bhagyashree; Davies, Heledd; Mamatharani, D. V.; Farheen, Dilsha; Treeck, Moritz; Karmodiya, Krishanpal (mBio, 2024)
Keywords: Antimalarials - pharmacology; artemisinin resistance; Artemisinins - pharmacology; Erythrocytes - parasitology; histone deacetylase; Histone Deacetylase 1 - genetics; Histone Deacetylase 1 - metabolism; Humans; malaria; Malaria, Falciparum - parasitology; Parasitology; PfHDAC1; Plasmodium falciparum; Plasmodium falciparum - drug effects; Plasmodium falciparum - genetics; Plasmodium falciparum - growth & development; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Reproduction, Asexual - genetics; Research Article; transcriptomics; artemisinin resistance; transcriptomics; Plasmodium falciparum; PfHDAC1; malaria; histone deacetylase