Metabolic Glycan Labeling of Cancer Cells Using Variably Acetylated Monosaccharides

• Published in: Bioconjugate chemistry Vol. 33; no. 8; pp. 1467 - 1473
• Main Authors: Parle, Daniel R., Bulat, Flaviu, Fouad, Shahd, Zecchini, Heather, Brindle, Kevin M., Neves, André A., Leeper, Finian J.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.08.2022
• Subjects: Acetylation; Biomarkers; Cancer; Glycan; Labeling; Medical imaging; Metabolic engineering; Monosaccharides; Monosaccharides - metabolism; Neoplasms - diagnostic imaging; Oligosaccharides; Polysaccharides - metabolism; Staining and Labeling - methods; Sugar; Tumor cell lines

Methylcyclopropene (Cyoc)-tagged tetra-acetylated monosaccharides, and in particular mannosamine derivatives, are promising tools for medical imaging of cancer using metabolic oligosaccharide engineering and the extremely fast inverse electron-demand Diels–Alder bioorthogonal reaction. However, the...