Minimal Crossover between Mutations Associated with Omicron Variant of SARS-CoV-2 and CD8 + T-Cell Epitopes Identified in COVID-19 Convalescent Individuals

• Published in: mBio Vol. 13; no. 2; p. e0361721
• Main Authors: Redd, Andrew D., Nardin, Alessandra, Kared, Hassen, Bloch, Evan M., Abel, Brian, Pekosz, Andrew, Laeyendecker, Oliver, Fehlings, Michael, Quinn, Thomas C., Tobian, Aaron A. R.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 26.04.2022
• Subjects: Amino Acids; CD8+ T cell; CD8-Positive T-Lymphocytes; convalescent patients; convalescent plasma; COVID-19; Epitopes, T-Lymphocyte - genetics; Humans; Immunology; Leukocytes, Mononuclear; Mutation; Observation; Omicron; SARS-CoV-2; SARS-CoV-2 - genetics; Spike Glycoprotein, Coronavirus - genetics; COVID-19; SARS-CoV-2; Omicron; convalescent patients; CD8+ T cell; convalescent plasma

The newly identified Omicron variant of concern contains more mutations than any of the previous variants described to date. In addition, many of the mutations associated with the Omicron variant are found in areas that are likely bound by neutralizing antibodies, suggesting that the first line of i...