Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2

• Published in: mBio Vol. 13; no. 1; p. e0290621
• Main Authors: Golden, Joseph W., Li, Rong, Cline, Curtis R., Zeng, Xiankun, Mucker, Eric M., Fuentes-Lao, Amadeo J., Spik, Kristin W., Williams, Janice A., Twenhafel, Nancy, Davis, Neil, Moore, Joshua L., Stevens, Stephen, Blue, Eugene, Garrison, Aura R., Larson, Deanna D., Stewart, Rebekah, Kunzler, Madelyn, Liu, Yanan, Wang, Zhongde, Hooper, Jay W.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 22.02.2022
• Subjects: Angiotensin-Converting Enzyme 2; Animals; cardiac lesions; COVID-19 - pathology; Cricetinae; Disease Models, Animal; Host-Microbial Interactions; Humans; K18-hACE2; Lung - pathology; Mice; Mice, Transgenic; nasal cavity; Peptidyl-Dipeptidase A; Research Article; SARS-CoV-2; transgenic hamsters; SARS-CoV-2; olfactory bulb; transgenic hamsters; nasal cavity; K18-hACE2; angiotensin-converting enzyme 2; neuropathology; cardiac lesions

The rapid emergence of SARS-CoV-2 has created a global health emergency. While most human SARS-CoV-2 disease is mild, some people develop severe, life-threatening disease. The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a global health emergency. While...