An Alternative Splicing Variant of the Mixed-Lineage Leukemia 5 Protein Is a Cellular Adhesion Receptor for ScaA of Orientia tsutsugamushi

• Published in: mBio Vol. 14; no. 1; p. e0154322
• Main Authors: Nguyen, Yen Thi Hai, Kim, Chaewon, Kim, Hong-Il, Kim, Yuri, Lee, Sang-Eun, Chang, Sunghoe, Ha, Na-Young, Cho, Nam-Hyuk
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28.02.2023
• Subjects: adhesion; Alternative Splicing; Animals; Bacterial Proteins - metabolism; Bacteriology; Humans; Ligands; Mammals - metabolism; Membrane Proteins - metabolism; mixed-lineage leukemia 5; Myeloid-Lymphoid Leukemia Protein - genetics; Myeloid-Lymphoid Leukemia Protein - metabolism; Orientia tsutsugamushi; Orientia tsutsugamushi - genetics; Orientia tsutsugamushi - metabolism; receptor; Research Article; scrub typhus; Scrub Typhus - microbiology; Scrub Typhus - prevention & control; Type V Secretion Systems - metabolism; vaccine; mixed-lineage leukemia 5; vaccine; receptor; adhesion; Orientia tsutsugamushi; scrub typhus

Scrub typhus is a mite-borne disease caused by the obligately intracellular bacterium Orientia tsutsugamushi. We previously demonstrated that ScaA, an autotransporter membrane protein of O. tsutsugamushi, is commonly shared in various genotypes and involved in adherence to host cells. Here, we ident...