Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns

• Published in: mBio Vol. 12; no. 2
• Main Authors: Ernandes, Michael J., Kagan, Jonathan C.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 13.04.2021
• Subjects: A549 Cells; Alarmins - pharmacology; Antiviral Agents - pharmacology; Cell Death - drug effects; DAMP; Humans; Immunity, Innate; innate immunity; Interferons - genetics; Interferons - metabolism; Kinetics; oxPAPC; Pathogen-Associated Molecular Pattern Molecules - pharmacology; Phosphatidylcholines - pharmacology; Research Article; RNA Viruses - drug effects; RNA Viruses - physiology; SARS; SARS-CoV-2 - drug effects; SARS-CoV-2 - physiology; Vesiculovirus - drug effects; Vesiculovirus - physiology; Viral Load; virus; Virus Internalization - drug effects; Virus Replication - drug effects; SARS; innate immunity; virus; oxPAPC; DAMP

In this work, we explored how a class of oxidized lipids, spontaneously created during tissue damage and unprogrammed cell lysis, block the earliest events in RNA virus infection in the human epithelium. This gives us novel insight into the ways that we view infection models, unveiling a built-in me...