The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir - Jochmans, Dirk; Liu, Cheng; Donckers, Kim; Stoycheva, Antitsa; Boland, Sandro; Stevens, Sarah K.; De Vita, Chloe; Vanmechelen, Bert; Maes, Piet; Trüeb, Bettina; Ebert, Nadine; Thiel, Volker; et al. (mBio, 2023)
Keywords: Antimicrobial Chemotherapy; antiviral agents; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; coronavirus; COVID-19; drug resistance mechanisms; Enzyme Inhibitors; Humans; protease inhibitors; Protease Inhibitors - chemistry; Protease Inhibitors - pharmacology; Research Article; SARS-CoV-2 - genetics; protease inhibitors; coronavirus; drug resistance mechanisms; antiviral agents