Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants

• Published in: mBio Vol. 12; no. 1
• Main Authors: Crits-Christoph, Alexander, Kantor, Rose S., Olm, Matthew R., Whitney, Oscar N., Al-Shayeb, Basem, Lou, Yue Clare, Flamholz, Avi, Kennedy, Lauren C., Greenwald, Hannah, Hinkle, Adrian, Hetzel, Jonathan, Spitzer, Sara, Koble, Jeffery, Tan, Asako, Hyde, Fred, Schroth, Gary, Kuersten, Scott, Banfield, Jillian F., Nelson, Kara L.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 19.01.2021
• Subjects: Base Sequence; California - epidemiology; Clinical Science and Epidemiology; COVID-19 - epidemiology; COVID-19 - virology; Environmental Microbiology; Genome, Viral; Genotype; Humans; Metagenome; Metagenomics; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Research Article; RNA, Viral - genetics; SARS-CoV-2 - genetics; SARS-CoV-2 - isolation & purification; Sewage - virology; Transcriptome; California; coronavirus; genomics; environmental microbiology; metagenomics

Viral genome sequencing has guided our understanding of the spread and extent of genetic diversity of SARS-CoV-2 during the COVID-19 pandemic. SARS-CoV-2 viral genomes are usually sequenced from nasopharyngeal swabs of individual patients to track viral spread. Viral genome sequencing has guided our...