Multiple Regulatory Mechanisms Control the Production of CmrRST, an Atypical Signal Transduction System in Clostridioides difficile

• Published in: mBio Vol. 13; no. 1; p. e0296921
• Main Authors: Garrett, Elizabeth M., Mehra, Anchal, Sekulovic, Ognjen, Tamayo, Rita
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 22.02.2021
• Subjects: Animals; Bacterial Proteins - metabolism; Bacteriology; bet-hedging; Biofilms; c-di-GMP; Clostridioides - metabolism; Clostridioides difficile - genetics; cyclic diguanylate; Cyclic GMP - metabolism; Gene Expression Regulation, Bacterial; motility; phase variation; phenotypic heterogeneity; Research Article; Second Messenger Systems; Signal Transduction - genetics; c-di-GMP; cyclic diguanylate; bet-hedging; biofilm; phenotypic heterogeneity; motility; population heterogeneity; phase variation

Clostridioides difficile is a leading cause of hospital-acquired intestinal infections in the United States. The CmrRST signal transduction system controls numerous physiological traits and processes in C. difficile , including cell and colony morphology, motility, biofilm formation, and virulence....