Structurally Ordered Nanowire Formation from Co-Assembly of DNA Origami and Collagen-Mimetic Peptides

• Published in: Journal of the American Chemical Society Vol. 139; no. 40; pp. 14025 - 14028
• Main Authors: Jiang, Tao, Meyer, Travis A, Modlin, Charles, Zuo, Xiaobing, Conticello, Vincent P, Ke, Yonggang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.10.2017; American Chemical Society (ACS)
• Subjects: arrays; BASIC BIOLOGICAL SCIENCES; biomimetic materials; design; DNA; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; nanosheets; nanowires; peptides; periodicity; physical properties; virus

We describe the co-assembly of two different building units: collagen-mimetic peptides and DNA origami. Two peptides CP ++ and sCP ++ are designed with a sequence comprising a central block (Pro-Hyp-Gly) and two positively charged domains (Pro-Arg-Gly) at both N- and C-termini. Co-assembly of peptid...