Metabolomics Meets Clinics: A Multivariate Analysis of Plasma and Urine Metabolic Signatures in Pulmonary Arterial Hypertension

• Published in: Journal of proteome research Vol. 23; no. 8; pp. 2795 - 2804
• Main Authors: Wawrzyniak, Renata, Grešner, Peter, Lewicka, Ewa, Macioszek, Szymon, Furga, Artur, Zieba, Bożena, J. Markuszewski, Michał, Da̧browska-Kugacka, Alicja
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.08.2024
• Subjects: Adult; Aged; Biomarkers - blood; Biomarkers - urine; butyric acid; Case-Control Studies; catheters; cholesterol; Discriminant Analysis; dyspnea; Female; Gas Chromatography-Mass Spectrometry; heart; Humans; hypertension; Hypertension, Pulmonary - blood; Hypertension, Pulmonary - diagnosis; Hypertension, Pulmonary - urine; Male; metabolites; Metabolome; metabolomics; Metabolomics - methods; Middle Aged; Multivariate Analysis; observational studies; proteome; Pulmonary Arterial Hypertension - blood; Pulmonary Arterial Hypertension - urine; pulmonary artery; pyruvic acid; threonine; urine; plasma; metabolomics; urine; pulmonary arterial hypertension; multivariate analysis

Pulmonary arterial hypertension (PAH) is a severe, multifactorial, and frequently misdiagnosed disorder. The aim of this observational study was to compare the plasma and urine metabolomic profiles of PAH patients and healthy control subjects. Plasma and urine metabolomic profiles were analyzed usin...