Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping

• Published in: ACS nano Vol. 9; no. 9; pp. 9357 - 9372
• Main Authors: Sun, Bingbing, Pokhrel, Suman, Dunphy, Darren R, Zhang, Haiyuan, Ji, Zhaoxia, Wang, Xiang, Wang, Meiying, Liao, Yu-Pei, Chang, Chong Hyun, Dong, Juyao, Li, Ruibin, Mädler, Lutz, Brinker, C. Jeffrey, Nel, André E, Xia, Tian
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.09.2015
• Subjects: Calcium - metabolism; Cell Line; Density; Doping; Foods; Fumed silica; Humans; Liver Cirrhosis - chemically induced; Liver Cirrhosis - pathology; Lung - drug effects; Lung - pathology; Lungs; Nanoparticles - adverse effects; Nanoparticles - chemistry; Pneumonia - chemically induced; Pneumonia - pathology; Reactive Oxygen Species - toxicity; Reduction; Silanes - chemistry; Silicon Dioxide - adverse effects; Silicon Dioxide - chemistry; Siloxanes; Structure-Activity Relationship; Titanium; United States; United States Food and Drug Administration; United States; doping; fumed silica; silanol groups; NLRP3 inflammasome; IL-1β; lung inflammation

The production of pyrogenic (fumed) silica is increasing worldwide at a 7% annual growth rate, including expanded use in food, pharmaceuticals, and other industrial products. Synthetic amorphous silica, including fumed silica, has been generally recognized as safe for use in food products by the Foo...