Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity

• Published in: The American journal of psychiatry Vol. 178; no. 1; pp. 48 - 64
• Main Authors: Xu, Jian, Liu, Rong-Jian, Fahey, Shaylyn, Frick, Luciana, Leckman, James, Vaccarino, Flora, Duman, Ronald S, Williams, Kyle, Swedo, Susan, Pittenger, Christopher
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.01.2021
• Subjects: Animals; Antibodies; Antigens; Autoantibodies - immunology; Autoimmune diseases; Autoimmune Diseases - complications; Autoimmune Diseases - immunology; Brain; Case-Control Studies; Child; Child, Preschool; Children & youth; Cholinergic Neurons - immunology; Cholinergic Neurons - physiology; Corpus Striatum - immunology; Corpus Striatum - physiopathology; Female; Humans; Immunoglobulin G - immunology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Obsessive compulsive disorder; Obsessive-Compulsive Disorder - complications; Obsessive-Compulsive Disorder - etiology; Obsessive-Compulsive Disorder - immunology; Streptococcal Infections - complications; Streptococcal Infections - immunology; Streptococcus infections; PANS; Basal Ganglia; Obsessive-Compulsive Disorder; PANDAS; Cholinergic Interneuron; Interneuron

Objective:Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even overnight, often after an infection. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS, describes such a situation after infection with Streptococcus pyogenes. PA...