Ureido-Derivatized Polymers Based on Both Poly(allylurea) and Poly(l-citrulline) Exhibit UCST-Type Phase Transition Behavior under Physiologically Relevant Conditions
There are few examples of polymers that exhibit upper critical solution temperature (UCST) behavior under physiological conditions of temperature, pH, and ionic strength. In this study, we demonstrated that polymers with ureido groups undergo UCST-type phase transitions under physiologically relevan...
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| Published in | Biomacromolecules Vol. 12; no. 10; pp. 3418 - 3422 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Chemical Society
10.10.2011
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| Abstract | There are few examples of polymers that exhibit upper critical solution temperature (UCST) behavior under physiological conditions of temperature, pH, and ionic strength. In this study, we demonstrated that polymers with ureido groups undergo UCST-type phase transitions under physiologically relevant conditions. Poly(allylurea) copolymers showed UCST behavior at pH 7.5 in 150 mM NaCl even at the low polymer concentration of 0.13 mg/mL. Their phase separation temperatures (T p) could be controlled up to 65 °C. Similar thermosensitivity was observed with copolypeptides consisting of l-citrulline having an ureido group. This is the first demonstration of a non-vinyl polymer that shows UCST behavior under physiologically relevant conditions. We suggest that the ureido modification will be useful for production of polymer materials with UCST behavior in aqueous media. |
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| AbstractList | There are few examples of polymers that exhibit upper critical solution temperature (UCST) behavior under physiological conditions of temperature, pH, and ionic strength. In this study, we demonstrated that polymers with ureido groups undergo UCST-type phase transitions under physiologically relevant conditions. Poly(allylurea) copolymers showed UCST behavior at pH 7.5 in 150 mM NaCl even at the low polymer concentration of 0.13 mg/mL. Their phase separation temperatures (Tp) could be controlled up to 65 ?C. Similar thermosensitivity was observed with copolypeptides consisting of l-citrulline having an ureido group. This is the first demonstration of a non-vinyl polymer that shows UCST behavior under physiologically relevant conditions. We suggest that the ureido modification will be useful for production of polymer materials with UCST behavior in aqueous media. There are few examples of polymers that exhibit upper critical solution temperature (UCST) behavior under physiological conditions of temperature, pH, and ionic strength. In this study, we demonstrated that polymers with ureido groups undergo UCST-type phase transitions under physiologically relevant conditions. Poly(allylurea) copolymers showed UCST behavior at pH 7.5 in 150 mM NaCl even at the low polymer concentration of 0.13 mg/mL. Their phase separation temperatures (T(p)) could be controlled up to 65 °C. Similar thermosensitivity was observed with copolypeptides consisting of L-citrulline having an ureido group. This is the first demonstration of a non-vinyl polymer that shows UCST behavior under physiologically relevant conditions. We suggest that the ureido modification will be useful for production of polymer materials with UCST behavior in aqueous media. There are few examples of polymers that exhibit upper critical solution temperature (UCST) behavior under physiological conditions of temperature, pH, and ionic strength. In this study, we demonstrated that polymers with ureido groups undergo UCST-type phase transitions under physiologically relevant conditions. Poly(allylurea) copolymers showed UCST behavior at pH 7.5 in 150 mM NaCl even at the low polymer concentration of 0.13 mg/mL. Their phase separation temperatures (T p) could be controlled up to 65 °C. Similar thermosensitivity was observed with copolypeptides consisting of l-citrulline having an ureido group. This is the first demonstration of a non-vinyl polymer that shows UCST behavior under physiologically relevant conditions. We suggest that the ureido modification will be useful for production of polymer materials with UCST behavior in aqueous media. |
| Author | Shimada, Naohiko Maruyama, Atsushi Maie, Kenji Kano, Arihiro Nakayama, Miki Ino, Haruka |
| AuthorAffiliation | Kyushu University |
| AuthorAffiliation_xml | – name: Kyushu University |
| Author_xml | – sequence: 1 givenname: Naohiko surname: Shimada fullname: Shimada, Naohiko – sequence: 2 givenname: Haruka surname: Ino fullname: Ino, Haruka – sequence: 3 givenname: Kenji surname: Maie fullname: Maie, Kenji – sequence: 4 givenname: Miki surname: Nakayama fullname: Nakayama, Miki – sequence: 5 givenname: Arihiro surname: Kano fullname: Kano, Arihiro – sequence: 6 givenname: Atsushi surname: Maruyama fullname: Maruyama, Atsushi email: maruyama@ms.ifoc.kyushu-u.ac.jp |
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| Keywords | Cloud point Salt effect Ionic strength Aminoacid copolymer pH Allylic derivative copolymer Aqueous solution Experimental study Saline solution Amine copolymer |
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| Snippet | There are few examples of polymers that exhibit upper critical solution temperature (UCST) behavior under physiological conditions of temperature, pH, and... |
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| SubjectTerms | Aminoacid polymers Applied sciences Biocompatible Materials - analysis Biocompatible Materials - chemical synthesis Biotechnology - methods Citrulline - chemistry Exact sciences and technology Hydrogen-Ion Concentration Organic polymers Phase Transition Physicochemistry of polymers Polymers - analysis Polymers - chemical synthesis Properties and characterization Sodium Chloride - chemistry Solution and gel properties Solutions Synthetic biopolymers Transition Temperature Urea - analogs & derivatives Urea - analysis Urea - chemical synthesis Water |
| Title | Ureido-Derivatized Polymers Based on Both Poly(allylurea) and Poly(l-citrulline) Exhibit UCST-Type Phase Transition Behavior under Physiologically Relevant Conditions |
| URI | http://dx.doi.org/10.1021/bm2010752 https://www.ncbi.nlm.nih.gov/pubmed/21928793 https://search.proquest.com/docview/903662432 https://search.proquest.com/docview/911160348 |
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