Prediction Error Representation in Individuals With Generalized Anxiety Disorder During Passive Avoidance

• Published in: The American journal of psychiatry Vol. 174; no. 2; pp. 110 - 117
• Main Authors: White, Stuart F, Geraci, Marilla, Lewis, Elizabeth, Leshin, Joseph, Teng, Cindy, Averbeck, Bruno, Meffert, Harma, Ernst, Monique, Blair, James R, Grillon, Christian, Blair, Karina S
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.02.2017
• Subjects: Adolescent; Adult; Anxiety; Anxiety Disorders - diagnosis; Anxiety Disorders - physiopathology; Anxiety Disorders - psychology; Avoidance Learning - physiology; Decision making; Decision Making - physiology; Emotional disorders; Errors; Female; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen - blood; Pathology; Patient-Specific Modeling; Pattern Recognition, Visual - physiology; Physiology; Prefrontal Cortex - physiology; Reference Values; Reinforcement, Psychology; Set, Psychology; Young Adult; Punishment; Striatum; Prediction Error; Generalized Anxiety Disorder; Reward; Decision-Making

Objective:Deficits in reinforcement-based decision making have been reported in generalized anxiety disorder. However, the pathophysiology of these deficits is largely unknown; published studies have mainly examined adolescents, and the integrity of core functional processes underpinning decision ma...