Genes To Mental Health (G2MH): A Framework to Map the Combined Effects of Rare and Common Variants on Dimensions of Cognition and Psychopathology

• Published in: The American journal of psychiatry Vol. 179; no. 3; pp. 189 - 203
• Main Authors: Jacquemont, Sébastien, Huguet, Guillaume, Klein, Marieke, Chawner, Samuel J.R.A, Donald, Kirsten A, van den Bree, Marianne B.M, Sebat, Jonathan, Ledbetter, David H, Constantino, John N, Earl, Rachel K, McDonald-McGinn, Donna M, van Amelsvoort, Therese, Swillen, Ann, O’Donnell-Luria, Anne H, Glahn, David C, Almasy, Laura, Eichler, Evan E, Scherer, Stephen W, Robinson, Elise, Bassett, Anne S, Martin, Christa Lese, Finucane, Brenda, Vorstman, Jacob A.S, Bearden, Carrie E, Gur, Raquel E
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.03.2022
• Subjects: Cognition; Cognitive ability; Genomics; Genotype & phenotype; Humans; Mental disorders; Mental Disorders - diagnosis; Mental Disorders - genetics; Mental Health; Psychiatry; Psychopathology; Intellectual Disabilities; Diagnosis and Classification; Autism Spectrum Disorder; Genetics/Genomics; Neurodevelopmental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders

Rare genomic disorders (RGDs) confer elevated risk for neurodevelopmental psychiatric disorders. In this era of intense genomics discoveries, the landscape of RGDs is rapidly evolving. However, there has not been comparable progress to date in scalable, harmonized phenotyping methods. As a result, b...