High-Throughput Transcriptomics of Water Extracts Detects Reductions in Biological Activity with Water Treatment Processes

• Published in: Environmental science & technology Vol. 58; no. 4; pp. 2027 - 2037
• Main Authors: Rogers, Jesse D., Leusch, Frederic D.L., Chambers, Bryant, Daniels, Kevin D., Everett, Logan J., Judson, Richard, Maruya, Keith, Mehinto, Alvine C., Neale, Peta A., Paul-Friedman, Katie, Thomas, Russell, Snyder, Shane A., Harrill, Joshua
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 30.01.2024; American Chemical Society (ACS)
• Subjects: Bioassays; Biological activity; Biological Assay; Breast carcinoma; Cell proliferation; Chemical pollution; Contaminants; Cost analysis; Drinking water; Ecological risk assessment; Engineering; Environmental Monitoring; Environmental Sciences & Ecology; Gene expression; Gene Expression Profiling; Humans; Industrial pollution; Occurrence, Fate, and Transport of Aquatic and Terrestrial Contaminants; Quality assessment; Reclaimed water; Surface water; Transcriptomics; Water monitoring; Water Pollutants, Chemical - analysis; Water Purification; Water Quality; Water quality management; Water supply; Water treatment; Xenoestrogens; differentially expressed genes; recycled water; MCF7; water cycle; water quality; high throughput transcriptomics

The presence of numerous chemical contaminants from industrial, agricultural, and pharmaceutical sources in water supplies poses a potential risk to human and ecological health. Current chemical analyses suffer from limitations, including chemical coverage and high cost, and broad-coverage in vitro...