Systematic analyses uncover robust salivary microbial signatures and host-microbiome perturbations in oral squamous cell carcinoma

• Published in: mSystems Vol. 10; no. 2; p. e0124724
• Main Authors: Han, Zewen, Hu, Yichen, Lin, Xin, Cheng, Hongyu, Dong, Biao, Liu, Xuan, Wu, Buling, Xu, Zhenjiang Zech
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 18.02.2025
• Subjects: age; Biomarkers; Cancer; Carcinoma, Squamous Cell - microbiology; Clinical Microbiology; Dysbacteriosis; Dysbiosis - microbiology; Female; Gender; Host Microbial Interactions; Humans; Invasiveness; Learning algorithms; Machine learning; Male; Malignancy; Maxillofacial; Meta-analysis; Microbiomes; Microbiota; Microorganisms; Mouth Neoplasms - microbiology; Oral carcinoma; Oral cavity; Oral squamous cell carcinoma; Pathogenesis; Research Article; Saliva; Saliva - microbiology; salivary microbiome; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - microbiology; meta-analysis; oral squamous cell carcinoma; gender; salivary microbiome; age

The oral cavity hosts a diverse microbial community that plays a crucial role in systemic and oral health. Accumulated research has investigated significant differences in the saliva microbiota associated with oral cancer, suggesting that microbiome dysbiosis may contribute to the pathogenesis of or...