HIV-1 RNAs whose transcription initiates from the third deoxyguanosine of GGG tract in the 5′ long terminal repeat serve as a dominant genome for efficient provirus DNA formation

• Published in: Journal of virology Vol. 98; no. 2; p. e0182523
• Main Authors: Yoshida, Takeshi, Kasuya, Yuho, Yamamoto, Hiroyuki, Kawai, Gota, Hanaki, Ken-ichi, Matano, Tetsuro, Masuda, Takao
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 20.02.2024
• Subjects: Deoxyguanosine - genetics; Genome and Regulation of Viral Gene Expression; Genome Replication and Regulation of Viral Gene Expression; Guanosine - genetics; HIV Long Terminal Repeat - genetics; HIV-1 - physiology; Proviruses - genetics; RNA, Viral - genetics; Terminal Repeat Sequences; Virology; HIV-1; genome; RNA; transcriptional initiation site; LTR; diversification; infectivity

Since the promoter for transcribing HIV-1 RNA is unique, all viral elements including genomic RNA and viral proteins have to be generated by the unique transcripts through ingenious mechanisms including RNA splicing and frameshifting during protein translation. Previous studies suggested a new mecha...