Conformational Selection in Biocatalytic Plastic Degradation by PETase

• Published in: ACS catalysis Vol. 12; no. 6; pp. 3397 - 3409
• Main Authors: Guo, Boyang, Vanga, Sudarsana Reddy, Lopez-Lorenzo, Ximena, Saenz-Mendez, Patricia, Ericsson, Sara Rönnblad, Fang, Yuan, Ye, Xinchen, Schriever, Karen, Bäckström, Eva, Biundo, Antonino, Zubarev, Roman A, Furó, István, Hakkarainen, Minna, Syrén, Per-Olof
• Format: Journal Article
• Language: English
• Published: American Chemical Society 18.03.2022
• Subjects: Chemistry - Biochemistry; conformational selection; enzyme engineering; gauche/trans; Kemi - biokemi; Medicin och hälsovetenskap; PET; plastic biodegradation; enzyme engineering; gauche/trans; PET; plastic biodegradation; conformational selection

Due to the steric effects imposed by bulky polymers, the formation of catalytically competent enzyme and substrate conformations is critical in the biodegradation of plastics. In poly­(ethylene terephthalate) (PET), the backbone adopts different conformations, gauche and trans, coexisting to differe...