Induction of HOX Genes by Hepatitis C Virus Infection via Impairment of Histone H2A Monoubiquitination

• Published in: Journal of virology Vol. 95; no. 6
• Main Authors: Kasai, Hirotake, Mochizuki, Kazuki, Tanaka, Tomohisa, Yamashita, Atsuya, Matsuura, Yoshiharu, Moriishi, Kohji
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 24.02.2021
• Subjects: Cell Line; Gene Expression Regulation; Genes, Homeobox - genetics; Hepacivirus - metabolism; Hepacivirus - physiology; Hepatitis C - genetics; Hepatitis C - metabolism; Hepatitis C - virology; Histone Code; Histones - metabolism; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Host-Pathogen Interactions; Humans; Polycomb Repressive Complex 1 - genetics; Polycomb Repressive Complex 1 - metabolism; Promoter Regions, Genetic; Proteasome Endopeptidase Complex - metabolism; Ubiquitination - physiology; Viral Core Proteins - metabolism; Virus-Cell Interactions; HCV; HOX gene; PRC1; monoubiquitination; H2A

Recently sustained virologic response can be achieved by direct-acting antiviral (DAA) therapy in most hepatitis C patients. Unfortunately, DAA therapy does not completely eliminate a risk of hepatocellular carcinoma (HCC). Hepatitis C virus (HCV) infection causes liver pathologies, including hepato...