C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection

New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an...

Full description

Saved in:
Bibliographic Details
Published inAntimicrobial agents and chemotherapy Vol. 60; no. 3; pp. 1902 - 1906
Main Authors Zhao, Dongming, Fukuyama, Satoshi, Sakai-Tagawa, Yuko, Takashita, Emi, Shoemaker, Jason E., Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.03.2016
Subjects
Animals
Antiviral Agents
Antiviral Agents - pharmacology
Benzoates
Benzoates - pharmacology
Cell Line
CREB-Binding Protein
CREB-Binding Protein - antagonists & inhibitors
CREB-Binding Protein - metabolism
Dogs
E1A-Associated p300 Protein
E1A-Associated p300 Protein - antagonists & inhibitors
E1A-Associated p300 Protein - metabolism
HEK293 Cells
Histone Acetyltransferases
Histone Acetyltransferases - antagonists & inhibitors
Humans
Influenza A virus
Influenza A virus - drug effects
Madin Darby Canine Kidney Cells
Mice
Mice, Inbred BALB C
Orthomyxoviridae Infections
Orthomyxoviridae Infections - drug therapy
Pyrazoles
Pyrazoles - pharmacology
Online AccessGet full text

Cover

Abstract New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.
AbstractList New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.
New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.
New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.
Author Zhao, Dongming
Takashita, Emi
Shoemaker, Jason E.
Kawaoka, Yoshihiro
Sakai-Tagawa, Yuko
Fukuyama, Satoshi
Author_xml – sequence: 1
  givenname: Dongming
  surname: Zhao
  fullname: Zhao, Dongming
  organization: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan, ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan
– sequence: 2
  givenname: Satoshi
  surname: Fukuyama
  fullname: Fukuyama, Satoshi
  organization: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan, ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan
– sequence: 3
  givenname: Yuko
  surname: Sakai-Tagawa
  fullname: Sakai-Tagawa, Yuko
  organization: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan
– sequence: 4
  givenname: Emi
  surname: Takashita
  fullname: Takashita, Emi
  organization: Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
– sequence: 5
  givenname: Jason E.
  surname: Shoemaker
  fullname: Shoemaker, Jason E.
  organization: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan, ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan
– sequence: 6
  givenname: Yoshihiro
  surname: Kawaoka
  fullname: Kawaoka, Yoshihiro
  organization: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan, ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA, Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26711748$$D View this record in MEDLINE/PubMed
BookMark eNp1kc1v1DAQxS1URLeFG2fkI0ib1k5sx7kgpVFLK1WA-Lpajnfcusrai-1UKhf-9brdUgGCkzWe3zy9mbeHdnzwgNBLSg4oreVh3w8HpCacV5Q_QQtKOlkJ3okdtCBEiIpJwnbRXkpXpNS8I8_Qbi1aSlsmF-jnIJhYYo3fh2uY8KYh5HD4dHxUHTm_cv4Cf4whg_PV5w0YZ53BZ_7SjS6HiIPFpy7lYgf3BvLNlKP2yULUCZa4zxn8rDOkMmKnGfwPjXv8zcX5_gdMdsE_R0-tnhK8eHj30deT4y_DaXX-4d3Z0J9XmkmWK1uLjjWMcatXbTOOTEJHBDEdX8lWAActrTQdNF1nTaM1a6Wlph7lyrYErGz20dut7mYe17Ay4IvZSW2iW-t4o4J26s-Od5fqIlwr1raCkKYIvH4QiOH7DCmrtUsGpkl7CHNStBWSi5rXrKBvtqhO61pdhTn6spqiRN0Fpkpg6j4wRXlhX_3u69HQr4QKsNwCJoaUIthH5D969V-4cVnfXbps5aZ_D90CWcixXA
CitedBy_id crossref_primary_10_3389_fimmu_2022_844749
crossref_primary_10_3390_toxins15070447
crossref_primary_10_1016_j_ymthe_2022_02_006
crossref_primary_10_3389_fmicb_2017_01211
crossref_primary_10_1016_j_intimp_2024_113674
crossref_primary_10_3390_v10100525
crossref_primary_10_1016_j_actbio_2018_04_021
crossref_primary_10_1038_s41598_023_39102_9
crossref_primary_10_1186_s12985_023_02200_1
crossref_primary_10_1016_j_crphar_2021_100058
crossref_primary_10_1016_j_bbrc_2017_12_058
crossref_primary_10_3389_fcimb_2021_804976
crossref_primary_10_1016_j_dci_2020_103640
crossref_primary_10_3389_fphar_2021_707610
crossref_primary_10_3389_fimmu_2021_771792
crossref_primary_10_1016_j_ijbiomac_2025_139973
crossref_primary_10_1002_slct_202205009
crossref_primary_10_1186_s13148_022_01402_8
crossref_primary_10_3390_ijms18112419
crossref_primary_10_3390_v16010131
crossref_primary_10_1016_j_ejmech_2019_05_078
crossref_primary_10_1371_journal_pone_0238907
crossref_primary_10_1042_BCJ20210200
crossref_primary_10_1016_j_cbpa_2018_06_015
crossref_primary_10_1016_j_intimp_2019_105885
Cites_doi 10.1074/jbc.M409024200
10.1371/journal.pone.0062482
10.1056/NEJMra1002842
10.1074/jbc.M301580200
10.1007/s00018-012-1254-4
10.1016/j.chembiol.2010.03.006
10.1183/09031936.05.00117504
10.1016/j.drudis.2009.06.008
10.1016/j.chom.2014.11.002
10.1164/rccm.2110060
10.1016/j.chembiol.2007.04.011
10.1016/j.foodchem.2009.09.011
10.1126/science.1229455
10.7326/0003-4819-156-7-201204030-00411
10.1099/vir.0.81766-0
10.1074/jbc.M402839200
10.1038/sj.leu.2401983
10.1128/JVI.01886-15
10.1038/sj.onc.1206376
10.1186/1752-0509-7-97
10.1128/MCB.22.13.4450-4462.2002
10.1073/pnas.1019109108
10.1146/annurev.pharmtox.45.120403.095825
10.1038/nprot.2014.180
10.1093/infdis/jiq012
10.1038/sj.onc.1210599
10.1016/S1473-3099(11)70295-X
10.1128/JVI.01140-10
10.1164/rccm.200305-659OC
10.1158/1541-7786.MCR-07-0324
10.1074/jbc.M114.559708
10.1128/AAC.04836-14
10.1099/vir.0.037648-0
10.1128/JVI.76.10.4699-4708.2002
ContentType Journal Article
Copyright Copyright © 2016, American Society for Microbiology. All Rights Reserved.
Copyright © 2016, American Society for Microbiology. All Rights Reserved. 2016 American Society for Microbiology
Copyright_xml – notice: Copyright © 2016, American Society for Microbiology. All Rights Reserved.
– notice: Copyright © 2016, American Society for Microbiology. All Rights Reserved. 2016 American Society for Microbiology
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1128/AAC.02055-15
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic


CrossRef
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
Pharmacy, Therapeutics, & Pharmacology
DocumentTitleAlternate C646 Suppresses Influenza A Virus Infection, Zhao et al
C646 Suppresses Influenza A Virus Infection
EISSN 1098-6596
EndPage 1906
ExternalDocumentID PMC4776003
02055-15
26711748
10_1128_AAC_02055_15
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: The Japan, Agency for Medical Research and Development
– fundername: The Ministry of Health, Labour and Welfare, Japan
– fundername: The Ministry of Education, Culture, Sports, Science and Technology, Japan
  funderid: http://dx.doi.org/10.13039/501100002241
– fundername: Japan Science and Technology Agency (JST)
– fundername: The Ministry of Education, Culture, Sports, Science and Technology, Japan
GroupedDBID ---
.55
.GJ
0R~
23M
2WC
39C
3O-
4.4
53G
5GY
5RE
5VS
6J9
AAGFI
AAYXX
ACGFO
ADBBV
AENEX
AGNAY
AGVNZ
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CITATION
CS3
DIK
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HH5
HYE
HZ~
H~9
J5H
K-O
KQ8
L7B
LSO
MVM
NEJ
O9-
OK1
P2P
RHI
RNS
RPM
RSF
TR2
UHB
VH1
W2D
W8F
WH7
WHG
WOQ
X7M
X7N
XOL
Y6R
ZGI
ZXP
~A~
CGR
CUY
CVF
ECM
EIF
NPM
RHF
-
0R
55
AAPBV
ABFLS
ADACO
BXI
HZ
ZA5
7X8
5PM
ID FETCH-LOGICAL-a484t-f26943445fad73bb48e9060c95d876e5ea8f8c9e399fc3aa478f1c2b8df70ef83
ISSN 0066-4804
1098-6596
IngestDate Thu Aug 21 18:30:53 EDT 2025
Thu Jul 10 22:53:47 EDT 2025
Tue Dec 28 13:58:59 EST 2021
Thu Jan 02 22:55:47 EST 2025
Tue Jul 01 04:32:31 EDT 2025
Thu Apr 24 23:09:13 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Language English
License Copyright © 2016, American Society for Microbiology. All Rights Reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-a484t-f26943445fad73bb48e9060c95d876e5ea8f8c9e399fc3aa478f1c2b8df70ef83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Citation Zhao D, Fukuyama S, Sakai-Tagawa Y, Takashita E, Shoemaker JE, Kawaoka Y. 2016. C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, attenuates influenza A virus infection. Antimicrob Agents Chemother 60:1902–1906. doi:10.1128/AAC.02055-15.
OpenAccessLink https://aac.asm.org/content/aac/60/3/1902.full.pdf
PMID 26711748
PQID 1768562524
PQPubID 23479
PageCount 5
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4776003
proquest_miscellaneous_1768562524
asm2_journals_10_1128_AAC_02055_15
pubmed_primary_26711748
crossref_primary_10_1128_AAC_02055_15
crossref_citationtrail_10_1128_AAC_02055_15
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-03-01
PublicationDateYYYYMMDD 2016-03-01
PublicationDate_xml – month: 03
  year: 2016
  text: 2016-03-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: 1752 N St., N.W., Washington, DC
PublicationTitle Antimicrobial agents and chemotherapy
PublicationTitleAbbrev Antimicrob Agents Chemother
PublicationTitleAlternate Antimicrob Agents Chemother
PublicationYear 2016
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References e_1_3_3_17_2
e_1_3_3_16_2
e_1_3_3_19_2
e_1_3_3_18_2
e_1_3_3_13_2
e_1_3_3_12_2
e_1_3_3_15_2
e_1_3_3_34_2
e_1_3_3_14_2
e_1_3_3_35_2
e_1_3_3_32_2
e_1_3_3_33_2
e_1_3_3_11_2
e_1_3_3_30_2
e_1_3_3_10_2
e_1_3_3_31_2
e_1_3_3_6_2
e_1_3_3_5_2
e_1_3_3_8_2
e_1_3_3_7_2
e_1_3_3_28_2
e_1_3_3_9_2
e_1_3_3_27_2
e_1_3_3_29_2
e_1_3_3_24_2
e_1_3_3_23_2
e_1_3_3_26_2
e_1_3_3_25_2
e_1_3_3_2_2
e_1_3_3_20_2
e_1_3_3_4_2
e_1_3_3_22_2
e_1_3_3_3_2
e_1_3_3_21_2
Balasubramanyam, K, Altaf, M, Varier, RA, Swaminathan, V, Ravindran, A, Sadhale, PP, Kundu, TK (B21) 2004; 279
Hsu, J, Santesso, N, Mustafa, R, Brozek, J, Chen, YL, Hopkins, JP, Cheung, A, Hovhannisyan, G, Ivanova, L, Flottorp, SA, Saeterdal, I, Wong, AD, Tian, J, Uyeki, TM, Akl, EA, Alonso-Coello, P, Smaill, F, Schunemann, HJ (B1) 2012; 156
Yang, XJ, Seto, E (B7) 2007; 26
Dokmanovic, M, Clarke, C, Marks, PA (B9) 2007; 5
Balasubramanyam, K, Varier, RA, Altaf, M, Swaminathan, V, Siddappa, NB, Ranga, U, Kundu, TK (B19) 2004; 279
Hayden, FG, de Jong, MD (B3) 2011; 203
Wang, F, Marshall, CB, Ikura, M (B14) 2013; 70
Drummond, DC, Noble, CO, Kirpotin, DB, Guo, Z, Scott, GK, Benz, CC (B8) 2005; 45
Mantelingu, K, Reddy, BA, Swaminathan, V, Kishore, AH, Siddappa, NB, Kumar, GV, Nagashankar, G, Natesh, N, Roy, S, Sadhale, PP, Ranga, U, Narayana, C, Kundu, TK (B10) 2007; 14
Ito, K, Caramori, G, Lim, S, Oates, T, Chung, KF, Barnes, PJ, Adcock, IM (B33) 2002; 166
Kitabayashi, I, Aikawa, Y, Yokoyama, A, Hosoda, F, Nagai, M, Kakazu, N, Abe, T, Ohki, M (B11) 2001; 15
Zhao, D, Fukuyama, S, Yamada, S, Lopes, TJ, Maemura, T, Katsura, H, Ozawa, M, Watanabe, S, Neumann, G, Kawaoka, Y (B30) 2015; 89
Lambert, LC, Fauci, AS (B2) 2010; 363
Cosío, BG, Mann, B, Ito, K, Jazrawi, E, Barnes, PJ, Chung, KF, Adcock, IM (B34) 2004; 170
Chen, TY, Chen, DY, Wen, HW, Ou, JL, Chiou, SS, Chen, JM, Wong, ML, Hsu, WL (B22) 2013; 8
Bowers, EM, Yan, G, Mukherjee, C, Orry, A, Wang, L, Holbert, MA, Crump, NT, Hazzalin, CA, Liszczak, G, Yuan, H, Larocca, C, Saldanha, SA, Abagyan, R, Sun, Y, Meyers, DJ, Marmorstein, R, Mahadevan, LC, Alani, RM, Cole, PA (B25) 2010; 17
Chen, D-Y, Shien, J-H, Tiley, L, Chiou, S-S, Wang, S-Y, Chang, T-J, Lee, Y-J, Chan, K-W, Hsu, W-L (B23) 2010; 119
Barnes, PJ, Adcock, IM, Ito, K (B12) 2005; 25
Balasubramanyam, K, Swaminathan, V, Ranganathan, A, Kundu, TK (B20) 2003; 278
Zhang, Y, Zhang, Q, Kong, H, Jiang, Y, Gao, Y, Deng, G, Shi, J, Tian, G, Liu, L, Liu, J, Guan, Y, Bu, Z, Chen, H (B31) 2013; 340
Dekker, FJ, Haisma, HJ (B13) 2009; 14
Hatakeyama, D, Shoji, M, Yamayoshi, S, Hirota, T, Nagae, M, Yanagisawa, S, Nakano, M, Ohmi, N, Noda, T, Kawaoka, Y, Kuzuhara, T (B24) 2014; 289
Subramanian, C, Hasan, S, Rowe, M, Hottiger, M, Orre, R, Robertson, ES (B16) 2002; 76
Takashita, E, Kiso, M, Fujisaki, S, Yokoyama, M, Nakamura, K, Shirakura, M, Sato, H, Odagiri, T, Kawaoka, Y, Tashiro, M (B27) 2015; 59
Matsuoka, Y, Matsumae, H, Katoh, M, Eisfeld, AJ, Neumann, G, Hase, T, Ghosh, S, Shoemaker, JE, Lopes, TJ, Watanabe, T, Watanabe, S, Fukuyama, S, Kitano, H, Kawaoka, Y (B5) 2013; 7
Lang, SE, Hearing, P (B18) 2003; 22
Sun, Y, Qin, K, Wang, J, Pu, J, Tang, Q, Hu, Y, Bi, Y, Zhao, X, Yang, H, Shu, Y, Liu, J (B32) 2011; 108
Osterholm, MT, Kelley, NS, Sommer, A, Belongia, EA (B4) 2012; 12
Octaviani, CP, Ozawa, M, Yamada, S, Goto, H, Kawaoka, Y (B29) 2010; 84
Watanabe, T, Kawakami, E, Shoemaker, JE, Lopes, TJ, Matsuoka, Y, Tomita, Y, Kozuka-Hata, H, Gorai, T, Kuwahara, T, Takeda, E, Nagata, A, Takano, R, Kiso, M, Yamashita, M, Sakai-Tagawa, Y, Katsura, H, Nonaka, N, Fujii, H, Fujii, K, Sugita, Y, Noda, T, Goto, H, Fukuyama, S, Watanabe, S, Neumann, G, Oyama, M, Kitano, H, Kawaoka, Y (B6) 2014; 16
Ozawa, M, Victor, ST, Taft, AS, Yamada, S, Li, C, Hatta, M, Das, SC, Takashita, E, Kakugawa, S, Maher, EA, Neumann, G, Kawaoka, Y (B28) 2011; 92
Zhang, Y, Jiang, Y, Geiser, V, Zhou, J, Jones, C (B15) 2006; 87
Lu, H, Pise-Masison, CA, Fletcher, TM, Schiltz, RL, Nagaich, AK, Radonovich, M, Hager, G, Cole, PA, Brady, JN (B17) 2002; 22
Eisfeld, AJ, Neumann, G, Kawaoka, Y (B26) 2014; 9
References_xml – ident: e_1_3_3_20_2
  doi: 10.1074/jbc.M409024200
– ident: e_1_3_3_23_2
  doi: 10.1371/journal.pone.0062482
– ident: e_1_3_3_3_2
  doi: 10.1056/NEJMra1002842
– ident: e_1_3_3_21_2
  doi: 10.1074/jbc.M301580200
– ident: e_1_3_3_15_2
  doi: 10.1007/s00018-012-1254-4
– ident: e_1_3_3_26_2
  doi: 10.1016/j.chembiol.2010.03.006
– ident: e_1_3_3_13_2
  doi: 10.1183/09031936.05.00117504
– ident: e_1_3_3_14_2
  doi: 10.1016/j.drudis.2009.06.008
– ident: e_1_3_3_7_2
  doi: 10.1016/j.chom.2014.11.002
– ident: e_1_3_3_34_2
  doi: 10.1164/rccm.2110060
– ident: e_1_3_3_11_2
  doi: 10.1016/j.chembiol.2007.04.011
– ident: e_1_3_3_24_2
  doi: 10.1016/j.foodchem.2009.09.011
– ident: e_1_3_3_32_2
  doi: 10.1126/science.1229455
– ident: e_1_3_3_2_2
  doi: 10.7326/0003-4819-156-7-201204030-00411
– ident: e_1_3_3_16_2
  doi: 10.1099/vir.0.81766-0
– ident: e_1_3_3_22_2
  doi: 10.1074/jbc.M402839200
– ident: e_1_3_3_12_2
  doi: 10.1038/sj.leu.2401983
– ident: e_1_3_3_31_2
  doi: 10.1128/JVI.01886-15
– ident: e_1_3_3_19_2
  doi: 10.1038/sj.onc.1206376
– ident: e_1_3_3_6_2
  doi: 10.1186/1752-0509-7-97
– ident: e_1_3_3_18_2
  doi: 10.1128/MCB.22.13.4450-4462.2002
– ident: e_1_3_3_33_2
  doi: 10.1073/pnas.1019109108
– ident: e_1_3_3_9_2
  doi: 10.1146/annurev.pharmtox.45.120403.095825
– ident: e_1_3_3_27_2
  doi: 10.1038/nprot.2014.180
– ident: e_1_3_3_4_2
  doi: 10.1093/infdis/jiq012
– ident: e_1_3_3_8_2
  doi: 10.1038/sj.onc.1210599
– ident: e_1_3_3_5_2
  doi: 10.1016/S1473-3099(11)70295-X
– ident: e_1_3_3_30_2
  doi: 10.1128/JVI.01140-10
– ident: e_1_3_3_35_2
  doi: 10.1164/rccm.200305-659OC
– ident: e_1_3_3_10_2
  doi: 10.1158/1541-7786.MCR-07-0324
– ident: e_1_3_3_25_2
  doi: 10.1074/jbc.M114.559708
– ident: e_1_3_3_28_2
  doi: 10.1128/AAC.04836-14
– ident: e_1_3_3_29_2
  doi: 10.1099/vir.0.037648-0
– ident: e_1_3_3_17_2
  doi: 10.1128/JVI.76.10.4699-4708.2002
– volume: 156
  start-page: 512
  year: 2012
  end-page: 524
  ident: B1
  article-title: Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-156-7-201204030-00411
– volume: 5
  start-page: 981
  year: 2007
  end-page: 989
  ident: B9
  article-title: Histone deacetylase inhibitors: overview and perspectives
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-07-0324
– volume: 84
  start-page: 10918
  year: 2010
  end-page: 10922
  ident: B29
  article-title: High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses
  publication-title: J Virol
  doi: 10.1128/JVI.01140-10
– volume: 70
  start-page: 3989
  year: 2013
  end-page: 4008
  ident: B14
  article-title: Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-012-1254-4
– volume: 8
  start-page: e62482
  year: 2013
  ident: B22
  article-title: Inhibition of enveloped viruses infectivity by curcumin
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0062482
– volume: 278
  start-page: 19134
  year: 2003
  end-page: 19140
  ident: B20
  article-title: Small molecule modulators of histone acetyltransferase p300
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M301580200
– volume: 87
  start-page: 1843
  year: 2006
  end-page: 1851
  ident: B15
  article-title: Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.81766-0
– volume: 22
  start-page: 4450
  year: 2002
  end-page: 4462
  ident: B17
  article-title: Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.22.13.4450-4462.2002
– volume: 340
  start-page: 1459
  year: 2013
  end-page: 1463
  ident: B31
  article-title: H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet
  publication-title: Science
  doi: 10.1126/science.1229455
– volume: 170
  start-page: 141
  year: 2004
  end-page: 147
  ident: B34
  article-title: Histone acetylase and deacetylase activity in alveolar macrophages and blood monocytes in asthma
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200305-659OC
– volume: 9
  start-page: 2663
  year: 2014
  end-page: 2681
  ident: B26
  article-title: Influenza A virus isolation, culture and identification
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2014.180
– volume: 59
  start-page: 2607
  year: 2015
  end-page: 2617
  ident: B27
  article-title: Characterization of a large cluster of influenza A(H1N1)pdm09 viruses cross-resistant to oseltamivir and peramivir during the 2013-2014 influenza season in Japan
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.04836-14
– volume: 108
  start-page: 4164
  year: 2011
  end-page: 4169
  ident: B32
  article-title: High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1019109108
– volume: 14
  start-page: 645
  year: 2007
  end-page: 657
  ident: B10
  article-title: Specific inhibition of p300-HAT alters global gene expression and represses HIV replication
  publication-title: Chem Biol
  doi: 10.1016/j.chembiol.2007.04.011
– volume: 166
  start-page: 392
  year: 2002
  end-page: 396
  ident: B33
  article-title: Expression and activity of histone deacetylases in human asthmatic airways
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.2110060
– volume: 203
  start-page: 6
  year: 2011
  end-page: 10
  ident: B3
  article-title: Emerging influenza antiviral resistance threats
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiq012
– volume: 14
  start-page: 942
  year: 2009
  end-page: 948
  ident: B13
  article-title: Histone acetyl transferases as emerging drug targets
  publication-title: Drug Discov Today
  doi: 10.1016/j.drudis.2009.06.008
– volume: 22
  start-page: 2836
  year: 2003
  end-page: 2841
  ident: B18
  article-title: The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1206376
– volume: 17
  start-page: 471
  year: 2010
  end-page: 482
  ident: B25
  article-title: Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor
  publication-title: Chem Biol
  doi: 10.1016/j.chembiol.2010.03.006
– volume: 89
  start-page: 11337
  year: 2015
  end-page: 11346
  ident: B30
  article-title: Molecular determinants of virulence and stability of a reporter-expressing H5N1 influenza A virus
  publication-title: J Virol
  doi: 10.1128/JVI.01886-15
– volume: 15
  start-page: 89
  year: 2001
  end-page: 94
  ident: B11
  article-title: Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22) (p11;q13) chromosome translocation
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2401983
– volume: 45
  start-page: 495
  year: 2005
  end-page: 528
  ident: B8
  article-title: Clinical development of histone deacetylase inhibitors as anticancer agents
  publication-title: Annu Rev Pharmacol Toxicol
  doi: 10.1146/annurev.pharmtox.45.120403.095825
– volume: 289
  start-page: 24980
  year: 2014
  end-page: 24994
  ident: B24
  article-title: A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M114.559708
– volume: 16
  start-page: 795
  year: 2014
  end-page: 805
  ident: B6
  article-title: Influenza virus-host interactome screen as a platform for antiviral drug development
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2014.11.002
– volume: 279
  start-page: 33716
  year: 2004
  end-page: 33726
  ident: B21
  article-title: Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M402839200
– volume: 279
  start-page: 51163
  year: 2004
  end-page: 51171
  ident: B19
  article-title: Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M409024200
– volume: 25
  start-page: 552
  year: 2005
  end-page: 563
  ident: B12
  article-title: Histone acetylation and deacetylation: importance in inflammatory lung diseases
  publication-title: Eur Respir J
  doi: 10.1183/09031936.05.00117504
– volume: 92
  start-page: 2879
  year: 2011
  end-page: 2888
  ident: B28
  article-title: Replication-incompetent influenza A viruses that stably express a foreign gene
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.037648-0
– volume: 26
  start-page: 5310
  year: 2007
  end-page: 5318
  ident: B7
  article-title: HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210599
– volume: 363
  start-page: 2036
  year: 2010
  end-page: 2044
  ident: B2
  article-title: Influenza vaccines for the future
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1002842
– volume: 12
  start-page: 36
  year: 2012
  end-page: 44
  ident: B4
  article-title: Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(11)70295-X
– volume: 119
  start-page: 1346
  year: 2010
  end-page: 1351
  ident: B23
  article-title: Curcumin inhibits influenza virus infection and haemagglutination activity
  publication-title: Food Chem
  doi: 10.1016/j.foodchem.2009.09.011
– volume: 76
  start-page: 4699
  year: 2002
  end-page: 4708
  ident: B16
  article-title: Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation
  publication-title: J Virol
  doi: 10.1128/JVI.76.10.4699-4708.2002
– volume: 7
  start-page: 97
  year: 2013
  ident: B5
  article-title: A comprehensive map of the influenza A virus replication cycle
  publication-title: BMC Syst Biol
  doi: 10.1186/1752-0509-7-97
SSID ssj0006590
Score 2.3327596
Snippet New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and...
SourceID pubmedcentral
proquest
asm2
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 1902
SubjectTerms Animals
Antiviral Agents
Antiviral Agents - pharmacology
Benzoates
Benzoates - pharmacology
Cell Line
CREB-Binding Protein
CREB-Binding Protein - antagonists & inhibitors
CREB-Binding Protein - metabolism
Dogs
E1A-Associated p300 Protein
E1A-Associated p300 Protein - antagonists & inhibitors
E1A-Associated p300 Protein - metabolism
HEK293 Cells
Histone Acetyltransferases
Histone Acetyltransferases - antagonists & inhibitors
Humans
Influenza A virus
Influenza A virus - drug effects
Madin Darby Canine Kidney Cells
Mice
Mice, Inbred BALB C
Orthomyxoviridae Infections
Orthomyxoviridae Infections - drug therapy
Pyrazoles
Pyrazoles - pharmacology
Title C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection
URI https://www.ncbi.nlm.nih.gov/pubmed/26711748
https://journals.asm.org/doi/10.1128/AAC.02055-15
https://www.proquest.com/docview/1768562524
https://pubmed.ncbi.nlm.nih.gov/PMC4776003
Volume 60
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbGEIgXBANGuckg2EubLhcncR-zamhC2lShDg1eIiex16hLOq0JqHvhB_KnOLZz6y7S4CVqbTdydb4cfz7x-Q5CH01YA2OPU4MnpgsbFCqMKBk5htSJ4Z7pJESJVR8eeQfH5MuJe7Kx8adzaqksomF8eWNeyf9YFdrArjJL9h8s29wUGuAz2BeuYGG43snGY08q8I77rH-0-MnP-ue65vL46_6esZfqfJWJFGJIc0MVmhdpDB5hlkbwHKvXA0olBHhmEPNidVYoFssvmK62GBRAqEtJRuFHqpbJJQNH8i29KFWLOsWVd-ltkBdpliptJ6lBcKrS51Tm3IxnVa5XE8P_MWMLzeHz06xeQSWUynm5YhnTAetisZylTRyIzVlqTNkp-6W6v5fzRRt7mMvCUJoN72dpN55hee2Brk4KgfRtnVOrh2mrStX15p5nEKrLFw-5duBSH9VzdZXc2sPrigUVkp2OuwY2ZHeWfvjq3bys2DJVIgjGQ2DXrmvoDNQrQt111z1034Y9i12HjipaAJPS-VDVpOssDJvudm8M1IAtM3udJl3b-1w9wtvhRNMn6HG1mcGBRuZTtMHzLfRAlzddbaGHh9XBjS20M9ES6asBnrYZf8sB3sGTVjx99Qz9lpgeYIYVorFE9G4Xz_gqnnGDZ7wQuMIzvobnAW7RjBs04wArNOMGzc_R8ef96fjAqIqEGIxQUhhCpmI7hLiCJb4TRYRysKIZj9wEFnruckYFjUcciLiIHcaIT4UV2xFNhG9yQZ0XaDOHib1EODL9RMgCDfYoIbHjRmTEHCDYzDSF5TtWD32QpgkrD7AM1QbapiHYL1T2Cy23h_q14cK4ktmX1V7Obhn9qRl9ruVlbhn3vsZACP5fvtRjOV-UMAffozKIYZMe2taYaO5ke75l-YT2kL-GlmaA1JZf78nTmdKYJ758Y--8ustffo0etQ_yG7RZXJT8LVD1InqnHoG_Ui3ngA
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=C646%2C+a+Novel+p300%2FCREB-Binding+Protein-Specific+Inhibitor+of+Histone+Acetyltransferase%2C+Attenuates+Influenza+A+Virus+Infection&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.au=Zhao%2C+Dongming&rft.au=Fukuyama%2C+Satoshi&rft.au=Sakai-Tagawa%2C+Yuko&rft.au=Takashita%2C+Emi&rft.date=2016-03-01&rft.pub=American+Society+for+Microbiology&rft.issn=0066-4804&rft.eissn=1098-6596&rft.volume=60&rft.issue=3&rft.spage=1902&rft.epage=1906&rft_id=info:doi/10.1128%2FAAC.02055-15&rft.externalDocID=02055-15
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0066-4804&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0066-4804&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0066-4804&client=summon