Xpert MTB/RIF Ultra Is Highly Sensitive for the Diagnosis of Tuberculosis Lymphadenitis in a High-HIV Setting

• Published in: Journal of clinical microbiology Vol. 59; no. 12; p. e0131621
• Main Authors: Minnies, Stephanie, Reeve, Byron W P, Rockman, Loren, Nyawo, Georgina, Naidoo, Charissa C, Kitchin, Natasha, Rautenbach, Cornelia, Wright, Colleen A, Whitelaw, Andrew, Schubert, Pawel, Warren, Robin M, Theron, Grant
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 18.11.2021
• Subjects: Antibiotics, Antitubercular - therapeutic use; Clinical Microbiology; HIV Infections - complications; HIV Infections - diagnosis; HIV Infections - drug therapy; Humans; Lymphadenitis - drug therapy; Mycobacteriology and Aerobic Actinomycetes; Mycobacterium tuberculosis - genetics; Rifampin - pharmacology; Sensitivity and Specificity; Tuberculosis, Lymph Node - diagnosis; Tuberculosis, Pulmonary - drug therapy; tuberculosis lymphadenitis; diagnostic accuracy; Xpert MTB/RIF Ultra

Tuberculosis lymphadenitis (TBL) is the most common extrapulmonary tuberculosis (EPTB) manifestation. Xpert MTB/RIF Ultra (Ultra) is a World Health Organization-endorsed diagnostic test, but performance data for TBL, including on noninvasive specimens, are limited. Fine-needle aspiration biopsy spec...